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<p>To study the risk factors for malnutrition in patients with hepatocellular carcinoma undergoing transarterial chemoembolisation (TACE), construct a risk prediction model and evaluate its predictive effectiveness. A retrospective study was conducted, selecting 194 cases of patients with liver cancer who received their first TACE treatment in the interventional department of a tertiary first-class hospital in Nantong, Jiangsu Province, between January 2019 and December 2023. General data and factors related to malnutrition were retrospectively collected, and the occurrence of malnutrition within 3&#xa0;months following TACE surgery was observed. Univariate analysis and multivariate logistic regression analysis were performed on the data, a predictive model was constructed and the model performance was evaluated using the Hosmer–Lemeshow (HL) test and receiver operating characteristic (ROC) curve analysis. The incidence of malnutrition was 36.08%. Multivariate logistic regression analysis showed that haemoglobin (Hb) (<i>P</i> = 0.048, odds ratio [OR] = 0.971), age (<i>P</i> = 0.017, OR = 1.068), Child–Pugh (CP) class score (<i>P</i> = 0.000, OR = 11.780), L3-psoas muscle index (L3-PMI) (<i>P</i> = 0.036, OR = 0.062) and albumin (ALB) (<i>P =</i> 0.000, OR = 0.804) were independent risk factors for malnutrition. The area under the ROC curve of the constructed model was 0.958, indicating its strong predictive power. The HL goodness-of-fit test (P &gt; 0.05) suggested that the model fit was good. Advanced age, high CP grade, low L3-PMI, low ALB and low Hb are independent risk factors for malnutrition in patients undergoing TACE for liver cancer. The constructed model can provide a scientific basis for nutritional management of patients.</p>

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Development and evaluation of a nutritional risk prediction model for patients with hepatocellular carcinoma undergoing transarterial chemoembolisation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月31日

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  • Chun-Xia Chen,
  • Xiang-Fan Chen,
  • Tian-Le Wang,
  • Hai-Yan Gu,
  • Guan-Hua Xu,
  • Zhi-Ming Cui

摘要

To study the risk factors for malnutrition in patients with hepatocellular carcinoma undergoing transarterial chemoembolisation (TACE), construct a risk prediction model and evaluate its predictive effectiveness. A retrospective study was conducted, selecting 194 cases of patients with liver cancer who received their first TACE treatment in the interventional department of a tertiary first-class hospital in Nantong, Jiangsu Province, between January 2019 and December 2023. General data and factors related to malnutrition were retrospectively collected, and the occurrence of malnutrition within 3 months following TACE surgery was observed. Univariate analysis and multivariate logistic regression analysis were performed on the data, a predictive model was constructed and the model performance was evaluated using the Hosmer–Lemeshow (HL) test and receiver operating characteristic (ROC) curve analysis. The incidence of malnutrition was 36.08%. Multivariate logistic regression analysis showed that haemoglobin (Hb) (P = 0.048, odds ratio [OR] = 0.971), age (P = 0.017, OR = 1.068), Child–Pugh (CP) class score (P = 0.000, OR = 11.780), L3-psoas muscle index (L3-PMI) (P = 0.036, OR = 0.062) and albumin (ALB) (P = 0.000, OR = 0.804) were independent risk factors for malnutrition. The area under the ROC curve of the constructed model was 0.958, indicating its strong predictive power. The HL goodness-of-fit test (P > 0.05) suggested that the model fit was good. Advanced age, high CP grade, low L3-PMI, low ALB and low Hb are independent risk factors for malnutrition in patients undergoing TACE for liver cancer. The constructed model can provide a scientific basis for nutritional management of patients.