<p>The North Yellow River Coalfield is susceptible to water inrush events due to groundwater influx, which has hindered the full exploitation of its coal resources and affected regional groundwater management. This study investigated the grouting parameters of directional drilling grouting reinforcement technology (DDGRT) based on the field engineering geological, and hydrogeological conditions. The efficacy of this technology in mitigating water inrush threats in coal mines was subsequently validated through a field case study. Initially, the hydrogeological characteristics of the Qiuji Coal Mine in the North Yellow River Coalfield was analyzed. This analysis identified some hydraulic connections between the No. 4 and No. 5 limestone layers overlying the coal seam and the Xuhui and Ordovician limestone below the mine floor. Subsequently, the physical and mechanical parameters and properties of the limestone were obtained by laboratory experiments and theoretical analysis. These data, in conjunction with previous research findings, were used to determine grouting parameters via numerical simulations of slurry diffusion. Finally, a DDGRT for controlling water inrush in the North Yellow River Coalfield was proposed, and the grouting effect was theoretically evaluated and empirically verified by field measurements. The results show that DDGRT effectively controlled and reinforced the aquifer by cutting off the hydraulic connections between the No. 4, No. 5, and Ordovician limestone, thereby facilitating the effective exploitation of the coal resources. The findings of this research provide a reference for implementing DDGRT in comparable underground engineering projects, including coal mines, gold mines, and tunnels susceptible to water inrush threats with similar engineering geological conditions.</p>