<p>The acceleration of digital innovation has widened the accessibility gap between users with and without disabilities, highlighting the need for inclusive software development frameworks that are both adaptable and scalable. This paper presents the MEEXUU framework, an inclusive design methodology that integrates principles from disability interaction, user-centered design, and inclusive design, extending the original MEEXUU approach previously applied to extended reality environments. Drawing on the ACD toolkit as a methodological foundation, the framework introduces a card-based toolkit and contextual support tools designed to simulate situational, temporal, and social constraints in real-world usage scenarios. To validate the framework, an expert evaluation was conducted with nine international specialists in human–computer interaction and inclusive design from Spain, Portugal, and Mexico. Each of the framework’s components was assessed along four dimensions, accuracy, relevance, coherence, and clarity, using a structured questionnaire. Cronbach’s alpha coefficients indicated good to excellent internal consistency in three categories (<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\alpha &gt; 0.72\)</EquationSource> </InlineEquation>), while clarity revealed opportunities for refinement (<InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(\alpha = 0.575\)</EquationSource> </InlineEquation>). The results provide promising insights into the MEEXUU framework’s potential as a versatile, theoretically grounded, and empirically supported tool for promoting digital inclusion. The paper contributes to both research and practice by embedding accessibility as a core element throughout the software development lifecycle.</p>