<p>While the use of social media has been researched extensively among older adults, gaining a deeper understanding of their e-health literacy is crucial for promoting meaningful interventions and enhancing their overall well-being. This study addresses this gap by investigating the roles of social media acceptance beliefs and usage satisfaction. The study surveyed 709 adults aged 55 and above from Taiwan (mean age = 69.17; 83% female; predominantly university-educated and active LINE users), using Structural Equation Modeling with bootstrapping for model analysis. Findings reveal that social media use is positively associated with older adults’ technology belief and social connection, which in turn are positively related to their e-health literacy. Furthermore, e-health literacy is positively correlated with the quality of life of older adults. Additionally, the relationship between social media use and quality of life is channeled through technology belief and information sharing, with e-health literacy serving as an intermediary factor. This study suggests a potential pathway in which social media use is related to higher e-health literacy, which may in turn contribute to enhanced quality of life among older adults, through various psychosocial factors and information access. Given the specific sample characteristics, the findings should be interpreted within the context of this population.</p>