<p>Based on the person-affect-cognition-execution theory, this research examines how generative artificial intelligence anxiety and fear of missing out contribute to problematic ChatGPT use. The study also tests whether the need for cognitive closure influences those two factors’ impacts on problematic ChatGPT use. With a total of 257 valid samples, data collection comes from 10 occupations in Taiwan that may be replaced by ChatGPT. The authors employ the software SmartPLS4.0 to evaluate the measurement model and the structural model. The results show that generative artificial intelligence anxiety has a significantly direct correlation with problematic ChatGPT use, and this generative artificial intelligence anxiety is mediated by fear of missing out. Furthermore, the need for cognitive closure significantly positively moderates the relationship between fear of missing out and problematic ChatGPT use. This paper extends the literature on the existing effect of generative artificial intelligence anxiety by considering professional workers who may be replaced by ChatGPT and by examining the mediating role of fear of missing out and the moderating role of need for cognitive closure as possible mechanisms between generative artificial intelligence anxiety and problematic ChatGPT use.</p>