This paper delves into the spectral norm aspect of the Generalized Column and Row Subset Selection (GCRSS) problem. Given a target matrix \(\textbf{A}\in \mathbb {R}^{n\times d}\) , the objective of GCRSS is to select a column submatrix \(\textbf{B}_{:,S}\in \mathbb {R}^{n\times k}\) from the source matrix \(\textbf{B}\in \mathbb {R}^{n\times d_B}\) and a row submatrix \(\textbf{C}_{R,:}\in \mathbb {R}^{r\times d}\) from the source matrix \(\textbf{C}\in \mathbb {R}^{n_C\times d}\) , such that the residual matrix \((\textbf{I}_n-\textbf{B}_{:,S}\textbf{B}_{:,S}^{\dagger })\textbf{A}(\textbf{I}_d-\textbf{C}_{R,:}^{\dagger } \textbf{C}_{R,:})\) has a small spectral norm. By employing the method of interlacing polynomials, we show that the smallest possible spectral norm of a residual matrix can be bounded by the largest root of a related expected characteristic polynomial. A deterministic polynomial time algorithm is provided for the spectral norm case of the GCRSS problem. We next apply our results to two specific GCRSS scenarios, one where \(r=0\) , simplifying the problem to the Generalized Column Subset Selection (GCSS) problem, and the other where \(\textbf{B}=\textbf{C}=\textbf{I}_d\) , reducing the problem to the submatrix selection problem. In the GCSS scenario, we connect the expected characteristic polynomials to the convolution of multi-affine polynomials, leading to the derivation of the first provable reconstruction bound on the spectral norm of a residual matrix. In the submatrix selection scenario, we show that for any sufficiently small \(\varepsilon >0\) and any square matrix \(\textbf{A}\in \mathbb {R}^{d\times d}\) , there exist two subsets \(S\subset [d]\) and \(R\subset [d]\) of sizes \(O(d\cdot \varepsilon ^2)\) such that \(\Vert \textbf{A}_{S,R}\Vert _2\le \varepsilon \cdot \Vert \textbf{A}\Vert _2\) . Unlike previous studies that have produced comparable results for very special cases where the matrix is either a zero-diagonal or a positive semidefinite matrix, our results apply universally to any square matrix \(\textbf{A}\) .