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<p>Many health care interventions are aimed at very young children, including public health measures such as vaccines, and new, high-cost medicines for rare diseases. This has led to increasing interest in evidence on the effectiveness and cost effectiveness of treatments in this age group. EQ-TIPS has been developed as a concise, generic health outcomes measure in 0–3-year-olds. Preference weights for EQ-TIPS are required to facilitate its use in&#xa0;economic evaluation. The aim of this paper is to consider the issues likely to be encountered in attempts to elicit stated preferences for EQ-TIPS. We begin by identifying the challenges that would arise if the existing EQ-5D-Y-3L (‘Y-3L’) valuation protocol were used as a starting point to value EQ-TIPS states. We highlight the challenges specific to valuing EQ-TIPS <i>over and above</i> the challenges already noted in valuing the Y-3L. We then discuss broader issues that may arise in valuing EQ-TIPS: (a) the potential influence on values of respondents taking into account the future consequences of developmental delay arising from poor health in infants, and (b) spill-over effects of poor health in infants on parents/caregivers. Methods used in valuing other instruments in this age group are reviewed. We conclude that eliciting stated preferences for EQ-TIPS would require adapting existing valuation methods. Parent-based valuation may be a viable approach, although methodological complexities remain. Alternative means of preference weighting EQ-TIPS, including mapping to the EQ-5D-Y, may offer a way forward.</p>

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Valuing health states for infants and toddlers: challenges and methodological considerations in EQ-TIPS preference elicitation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Nancy Devlin,
  • Bram Roudijk,
  • Michael Herdman,
  • Elly Stolk,
  • Richard Norman,
  • Simone Kreimeier,
  • Janine Verstraete

摘要

Many health care interventions are aimed at very young children, including public health measures such as vaccines, and new, high-cost medicines for rare diseases. This has led to increasing interest in evidence on the effectiveness and cost effectiveness of treatments in this age group. EQ-TIPS has been developed as a concise, generic health outcomes measure in 0–3-year-olds. Preference weights for EQ-TIPS are required to facilitate its use in economic evaluation. The aim of this paper is to consider the issues likely to be encountered in attempts to elicit stated preferences for EQ-TIPS. We begin by identifying the challenges that would arise if the existing EQ-5D-Y-3L (‘Y-3L’) valuation protocol were used as a starting point to value EQ-TIPS states. We highlight the challenges specific to valuing EQ-TIPS over and above the challenges already noted in valuing the Y-3L. We then discuss broader issues that may arise in valuing EQ-TIPS: (a) the potential influence on values of respondents taking into account the future consequences of developmental delay arising from poor health in infants, and (b) spill-over effects of poor health in infants on parents/caregivers. Methods used in valuing other instruments in this age group are reviewed. We conclude that eliciting stated preferences for EQ-TIPS would require adapting existing valuation methods. Parent-based valuation may be a viable approach, although methodological complexities remain. Alternative means of preference weighting EQ-TIPS, including mapping to the EQ-5D-Y, may offer a way forward.