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Purpose <p>There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV).</p> Methods <p>We examined three fresh-frozen temporal bones (TB), two donated by white males and one by a Black female, using dynamic synchrotron-based X-ray microtomography for 256 and 512&#xa0;Hz, stimulated at 110&#xa0;dB and 120&#xa0;dB sound pressure level (SPL). In addition, we performed measurements on these TBs using 1D LDV, a well-established method.</p> Results <p>The normalized displacement values (µm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5–10&#xa0;dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques.</p> Conclusion <p>In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear’s biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.</p>

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Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月14日

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  • Aleksandra Ivanovic,
  • Jeffrey Tao Cheng,
  • Margaux Schmeltz,
  • Wilhelm Wimmer,
  • Christian M. Schlepuetz,
  • Aaron K. Remenschneider,
  • Anne Bonnin,
  • Lukas Anschuetz

摘要

Purpose

There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV).

Methods

We examined three fresh-frozen temporal bones (TB), two donated by white males and one by a Black female, using dynamic synchrotron-based X-ray microtomography for 256 and 512 Hz, stimulated at 110 dB and 120 dB sound pressure level (SPL). In addition, we performed measurements on these TBs using 1D LDV, a well-established method.

Results

The normalized displacement values (µm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5–10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques.

Conclusion

In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear’s biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.