Scholarlink

Background <p>Thrombin is a serine protease that plays an important role in blood coagulation and has been implicated in kidney diseases, particularly glomerular disorders. In this study, we aimed to evaluate urinary thrombin in different types of kidney disease and investigate whether it can be used as a biomarker for the presence of segmental sclerosis lesions in IgA nephropathy.</p> Methods <p>We enrolled 151 patients aged ≥ 18&#xa0;years who underwent renal biopsy at Kumamoto University Hospital or two of its affiliate hospitals between November 2016 and September 2021. Urine samples were obtained from patients, and urinary thrombin antigen levels were measured using a previously established highly sensitive enzyme-linked immunosorbent assay. We evaluated urinary thrombin in different types of kidney disease, focusing on IgA nephropathy, and assessed the association between urinary thrombin and histological severity classification (Oxford classification), especially S lesions.</p> Results <p>Among the patients with kidney disease, thrombinuria was more prevalent in those with focal segmental glomerulosclerosis [60%; 9/15]. In 34 patients with IgA nephropathy, the logistic regression model, using the presence of S lesions as the outcome variable, demonstrated that the odds ratios for thrombinuria and proteinuria were 7.20 and 2.82, respectively. The areas under the receiver operating characteristic curve (AUROC) regarding the models for thrombinuria and proteinuria were 0.73 and 0.56, respectively, with both differences being significant (<i>p</i> = 0.04).</p> Conclusions <p>Our findings suggest that thrombinuria may be a novel biomarker for kidney disease, particularly for segmental sclerosis lesions in IgA nephropathy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Urinary thrombin as a non-invasive biomarker in renal diseases: a possible role in the detection of segmental sclerosis lesions in IgA nephropathy

  • 期刊论文

  • 发表日期：

    2026年2月2日

查看全文
  • Yoshikazu Miyasato,
  • Terumasa Nakagawa,
  • Yasunobu Iwata,
  • Yutaka Kakizoe,
  • Yuichiro Izumi,
  • Yu Nagayoshi,
  • Kayo Nishiguchi,
  • Miyuki Nakagawa,
  • Masashi Mukoyama,
  • Hideki Yokoi,
  • Yasunori Kitamoto,
  • Masataka Adachi

摘要

Background

Thrombin is a serine protease that plays an important role in blood coagulation and has been implicated in kidney diseases, particularly glomerular disorders. In this study, we aimed to evaluate urinary thrombin in different types of kidney disease and investigate whether it can be used as a biomarker for the presence of segmental sclerosis lesions in IgA nephropathy.

Methods

We enrolled 151 patients aged ≥ 18 years who underwent renal biopsy at Kumamoto University Hospital or two of its affiliate hospitals between November 2016 and September 2021. Urine samples were obtained from patients, and urinary thrombin antigen levels were measured using a previously established highly sensitive enzyme-linked immunosorbent assay. We evaluated urinary thrombin in different types of kidney disease, focusing on IgA nephropathy, and assessed the association between urinary thrombin and histological severity classification (Oxford classification), especially S lesions.

Results

Among the patients with kidney disease, thrombinuria was more prevalent in those with focal segmental glomerulosclerosis [60%; 9/15]. In 34 patients with IgA nephropathy, the logistic regression model, using the presence of S lesions as the outcome variable, demonstrated that the odds ratios for thrombinuria and proteinuria were 7.20 and 2.82, respectively. The areas under the receiver operating characteristic curve (AUROC) regarding the models for thrombinuria and proteinuria were 0.73 and 0.56, respectively, with both differences being significant (p = 0.04).

Conclusions

Our findings suggest that thrombinuria may be a novel biomarker for kidney disease, particularly for segmental sclerosis lesions in IgA nephropathy.