Scholarlink

Background <p>Pediatric kidney failure carries high cardiovascular risk. Kidney transplantation is the preferred therapy, yet residual endothelial dysfunction contributes to post-transplant morbidity. The current study determines whether pre-transplant hemodialysis versus peritoneal dialysis affects post-transplant levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), P-selectin, and nitric oxide (NO) in pediatric kidney transplant recipients.</p> Methods <p>In a cross-sectional study, we assessed 53 children 6–24 months after kidney transplantation. Fourteen had received peritoneal dialysis and 39 hemodialysis pre-transplant. Serum sICAM-1, sVCAM-1, and P-selectin were measured using a Luminex-based assay and NO by chemiluminescence.</p> Results <p>Baseline demographic characteristics were similar between groups. Peritoneal dialysis was associated with lower sICAM-1 (<i>p</i>= 0.028) and sVCAM-1 (<i>p</i>= 0.006) and higher NO (<i>p</i>&lt; 0.001), whereas P-selectin did not differ (<i>p</i>= 0.308). sICAM-1 correlated positively with P-selectin (<i>r=</i> 0.286, <i>p=</i> 0.038) and dialysis duration (<i>r=</i> 0.303, <i>p=</i> 0.028) and inversely with glomerular filtration rate (<i>r</i>=−0.328, <i>p</i>= 0.016). sVCAM-1 correlated positively with dialysis exposure time (<i>r=</i> 0.340, <i>p=</i> 0.013) and negatively with NO (<i>r</i>=−0.393, <i>p</i>= 0.004). Dialysis type and duration predicted sVCAM-1 (<i>R</i><sup>2</sup>=0.199), dialysis exposure time-predicted sICAM-1 (<i>R</i><sup>2</sup>=0.203), and modality-predicted NO (<i>R</i><sup>2</sup>=0.252).</p> Conclusions <p>In pediatric kidney transplant recipients, pre-transplant peritoneal dialysis is associated with reduced endothelial activation and enhanced NO bioavailability compared with hemodialysis, suggesting a vascular benefit that could inform dialysis selection prior to transplantation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of dialysis therapies on circulating levels of endothelial markers after kidney transplant in children: focus on positive aspect of peritoneal dialysis

  • 期刊论文

  • 发表日期：

    2025年12月13日

查看全文
  • Giovanna Assoni Rodrigues,
  • Fernanda Thomazini,
  • Claudia Rosso Felipe,
  • José Medina Pestana,
  • Maria do Carmo Franco

摘要

Background

Pediatric kidney failure carries high cardiovascular risk. Kidney transplantation is the preferred therapy, yet residual endothelial dysfunction contributes to post-transplant morbidity. The current study determines whether pre-transplant hemodialysis versus peritoneal dialysis affects post-transplant levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), P-selectin, and nitric oxide (NO) in pediatric kidney transplant recipients.

Methods

In a cross-sectional study, we assessed 53 children 6–24 months after kidney transplantation. Fourteen had received peritoneal dialysis and 39 hemodialysis pre-transplant. Serum sICAM-1, sVCAM-1, and P-selectin were measured using a Luminex-based assay and NO by chemiluminescence.

Results

Baseline demographic characteristics were similar between groups. Peritoneal dialysis was associated with lower sICAM-1 (p= 0.028) and sVCAM-1 (p= 0.006) and higher NO (p< 0.001), whereas P-selectin did not differ (p= 0.308). sICAM-1 correlated positively with P-selectin (r= 0.286, p= 0.038) and dialysis duration (r= 0.303, p= 0.028) and inversely with glomerular filtration rate (r=−0.328, p= 0.016). sVCAM-1 correlated positively with dialysis exposure time (r= 0.340, p= 0.013) and negatively with NO (r=−0.393, p= 0.004). Dialysis type and duration predicted sVCAM-1 (R2=0.199), dialysis exposure time-predicted sICAM-1 (R2=0.203), and modality-predicted NO (R2=0.252).

Conclusions

In pediatric kidney transplant recipients, pre-transplant peritoneal dialysis is associated with reduced endothelial activation and enhanced NO bioavailability compared with hemodialysis, suggesting a vascular benefit that could inform dialysis selection prior to transplantation.