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<p>Renal ischemia–reperfusion injury (RIRI) is a major cause of acute kidney failure. Recent studies have shown that RIRI mechanism is closely related to abnormal mitochondrial biogenesis, fusion, fission, and autophagy. Maintaining normal mitochondrial function is essential for RIRI treatment. Therefore, it is important to explore molecular mechanisms of RIRI and relevant therapeutic targets. This review describes the role of mitochondria in RIRI and summarises information about potential drugs that regulate mitochondrial function, with the aim of providing ideas for clinical targeting of mitochondria to prevent and treat RIRI.</p>

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Advances in understanding the role of mitochondria in renal ischemia–reperfusion injury

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月8日

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  • Huimeng Li,
  • Xiangbo Wang,
  • Danfang Deng,
  • Shenhui Lv,
  • Lili Huang,
  • Xiaoqin Wang

摘要

Renal ischemia–reperfusion injury (RIRI) is a major cause of acute kidney failure. Recent studies have shown that RIRI mechanism is closely related to abnormal mitochondrial biogenesis, fusion, fission, and autophagy. Maintaining normal mitochondrial function is essential for RIRI treatment. Therefore, it is important to explore molecular mechanisms of RIRI and relevant therapeutic targets. This review describes the role of mitochondria in RIRI and summarises information about potential drugs that regulate mitochondrial function, with the aim of providing ideas for clinical targeting of mitochondria to prevent and treat RIRI.