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Background <p>The association between the variability of triglyceride (TG) and chronic kidney disease (CKD) progression remains unclear. We examined whether intraindividual variability in fasting TG was associated with the exacerbation of CKD.</p> Methods <p>We conducted a retrospective and observational study. 18,339 participants, who went through medical checkups and had checked their estimated glomerular filtration rate (eGFR) and semi-quantitative proteinuria by urine dipstick every year since 2017 for 4&#xa0;years were registered. Variability in fasting TG was determined using the standard deviation (SD), and maximum minus minimum difference (MMD) between 2017 and 2021. The primary end point for the analysis of eGFR decline was eGFR &lt; 60&#xa0;mL/min/1.73&#xa0;m<sup>2</sup>. The secondary end point for the analysis of proteinuria was the incidence of proteinuria ≥ ( ±) by urine dipstick.</p> Results <p>The renal survival was lower in the higher-SD, and higher-MMD groups than in the lower-SD, and lower-MMD groups, respectively (log-rank test <i>p</i> &lt; 0.001, and &lt; 0.001, respectively). Lower SD and lower MMD were significantly associated with renal survival in the adjusted model (hazard ratio (HR), 1.12; 95% confidence intervals (CI), 1.04–1.21, and HR, 1.13; 95% CI 1.05–1.23, respectively). The non-incidence of proteinuria was lower in the higher-SD, and higher-MMD groups than in the lower-SD, and lower-MMD groups, respectively (log-rank test <i>p</i> &lt; 0.001 and &lt; 0.001, respectively).</p> Conclusion <p>Fasting TG variability was associated with CKD progression in participants who went through medical checkups.</p>

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The association of fasting triglyceride variability with renal dysfunction and proteinuria in medical checkup participants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月28日

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  • Natsumi Matsuoka-Uchiyama,
  • Haruhito A. Uchida,
  • Tomohiko Asakawa,
  • Yoshimasa Sakurabu,
  • Katsuyoshi Katayama,
  • Shugo Okamoto,
  • Yasuhiro Onishi,
  • Keiko Tanaka,
  • Hidemi Takeuchi,
  • Rika Takemoto,
  • Ryoko Umebayashi,
  • Jun Wada

摘要

Background

The association between the variability of triglyceride (TG) and chronic kidney disease (CKD) progression remains unclear. We examined whether intraindividual variability in fasting TG was associated with the exacerbation of CKD.

Methods

We conducted a retrospective and observational study. 18,339 participants, who went through medical checkups and had checked their estimated glomerular filtration rate (eGFR) and semi-quantitative proteinuria by urine dipstick every year since 2017 for 4 years were registered. Variability in fasting TG was determined using the standard deviation (SD), and maximum minus minimum difference (MMD) between 2017 and 2021. The primary end point for the analysis of eGFR decline was eGFR < 60 mL/min/1.73 m2. The secondary end point for the analysis of proteinuria was the incidence of proteinuria ≥ ( ±) by urine dipstick.

Results

The renal survival was lower in the higher-SD, and higher-MMD groups than in the lower-SD, and lower-MMD groups, respectively (log-rank test p < 0.001, and < 0.001, respectively). Lower SD and lower MMD were significantly associated with renal survival in the adjusted model (hazard ratio (HR), 1.12; 95% confidence intervals (CI), 1.04–1.21, and HR, 1.13; 95% CI 1.05–1.23, respectively). The non-incidence of proteinuria was lower in the higher-SD, and higher-MMD groups than in the lower-SD, and lower-MMD groups, respectively (log-rank test p < 0.001 and < 0.001, respectively).

Conclusion

Fasting TG variability was associated with CKD progression in participants who went through medical checkups.