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Background <p>Functional outcomes and quality of life (QoL) of transverse coloplasty pouch (TCP) in intersphincteric resection (ISR) for ultralow rectal cancer remain poorly understood.</p> Methods <p>A prospective analysis was conducted on patients who received ISR treatment from January 2020 to May&#xa0;2022. Patients were divided into TCP and straight coloanal anastomosis (SCAA) groups. Comparisons were made for low anterior resection syndrome (LARS) score, Wexner incontinence score (WIS), Kirwan’s incontinence score, visual analog scale (VAS), and fecal incontinence quality of life (FIQL) questionnaire at 3, 6, and 12&#xa0;months post ileostomy closure. Additionally, anorectal manometry outcomes were compared pre ileostomy closure.</p> Results <p>A total of 75 patients were included, with 25 in the TCP group and 50 in the SCAA group. At 3, 6, 12&#xa0;months post ileostomy closure, the TCP group showed significantly lower LARS (31, 30, 28; <i>p</i> = 0.033, 0.044, 0.019, respectively), WIS (11.04, 9.92, 7.32; <i>p</i> = 0.025, 0.043, 0.007, respectively), and Kirwan’s incontinence scores (<i>p</i> = 0.044, 0.033, 0.022). Additionally, the TCP group showed higher VAS (5, 6, 7; <i>p</i> = 0.004, 0.006, 0.005, respectively) and FIQL summary scores (2.67, 2.79, 2.86; <i>p</i> = 0.001, 0.002, 0.004, respectively). Prior to ileostomy closure, the rectal first sensation and maximum tolerance volumes were significantly higher in the TCP group compared to the SCAA group (22&#xa0;ml vs. 20&#xa0;ml, 51.56&#xa0;ml vs. 34.52&#xa0;ml; <i>p</i> = 0.019, 0.038, respectively). There were no significant differences in postoperative complications or recurrence rates between the groups.</p> Conclusions <p>TCP is a safe technique, which may improve bowel function and QoL in ISR patients with low rectal cancer within 1&#xa0;year.</p>

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Functional outcomes and quality of life after intersphincteric resection with transverse coloplasty pouch anastomosis for ultralow rectal cancer: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月9日

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  • Y. Jia,
  • B. Zhang,
  • Y. Zhao,
  • G. Zhuo,
  • X. Song,
  • J. Xiang,
  • J. Ding

摘要

Background

Functional outcomes and quality of life (QoL) of transverse coloplasty pouch (TCP) in intersphincteric resection (ISR) for ultralow rectal cancer remain poorly understood.

Methods

A prospective analysis was conducted on patients who received ISR treatment from January 2020 to May 2022. Patients were divided into TCP and straight coloanal anastomosis (SCAA) groups. Comparisons were made for low anterior resection syndrome (LARS) score, Wexner incontinence score (WIS), Kirwan’s incontinence score, visual analog scale (VAS), and fecal incontinence quality of life (FIQL) questionnaire at 3, 6, and 12 months post ileostomy closure. Additionally, anorectal manometry outcomes were compared pre ileostomy closure.

Results

A total of 75 patients were included, with 25 in the TCP group and 50 in the SCAA group. At 3, 6, 12 months post ileostomy closure, the TCP group showed significantly lower LARS (31, 30, 28; p = 0.033, 0.044, 0.019, respectively), WIS (11.04, 9.92, 7.32; p = 0.025, 0.043, 0.007, respectively), and Kirwan’s incontinence scores (p = 0.044, 0.033, 0.022). Additionally, the TCP group showed higher VAS (5, 6, 7; p = 0.004, 0.006, 0.005, respectively) and FIQL summary scores (2.67, 2.79, 2.86; p = 0.001, 0.002, 0.004, respectively). Prior to ileostomy closure, the rectal first sensation and maximum tolerance volumes were significantly higher in the TCP group compared to the SCAA group (22 ml vs. 20 ml, 51.56 ml vs. 34.52 ml; p = 0.019, 0.038, respectively). There were no significant differences in postoperative complications or recurrence rates between the groups.

Conclusions

TCP is a safe technique, which may improve bowel function and QoL in ISR patients with low rectal cancer within 1 year.