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Background <p>Adult granulosa cell tumors (AGCTs) are rare low-grade malignant ovarian tumors, with 80–90% diagnosed at FIGO stage I. This study aimed to identify prognostic factors and refine management for stage I AGCT.</p> Methods <p>In this 30-year retrospective cohort study, patients with stage I AGCT between January 1988 and January 2024 were selected and reviewed in total cohort and subgroups according to tumor stage.</p> Results <p>This retrospective study analyzed 333 eligible AGCT cases, including 196 patients (58.9%) with FIGO stage IA and 137 (41.1%) with stage IC. After a median follow-up of 138.5 ± 108.0&#xa0;months, recurrence occurred in 55 patients (40.1%) in the IC group, significantly higher&#xa0;than that&#xa0;in the IA group (38 patients, 19.4%; <i>P</i> &lt; 0.001, FDR = 0.005). Approximately half of recurrences in both groups were intra-abdominal, with comparable median recurrence intervals. Multivariate logistic regression identified stage IC (<i>P</i> = 0.001), incomplete staging surgery (<i>P</i> = 0.015) and adjuvant chemotherapy (<i>P</i> = 0.002) independent predictors of increased recurrence. In the propensity-matched cohort (<i>n</i> = 188), adjuvant chemotherapy showed no significant association with recurrence (<i>P</i> = 0.067). Cox multivariate analysis revealed stage IC&#xa0;and incomplete staging surgery as independent prognostic factors for worse DFS in early-stage disease&#xa0;(<i>P</i> = 0.001&#xa0;and&#xa0;0.012, respectively). Notably, complete staging surgery was associated with improved DFS specifically in stage IC patients (<i>P</i> = 0.016).</p> Conclusions <p>Unilateral salpingo-oophorectomy instead of simple cystectomy demonstrated a favorable safety profile in reproductive patients with stage I AGCT. Comprehensive surgical staging without lymphadenectomy should be considered as a viable treatment strategy, especially in the stage IC disease, manifesting a significantly higher recurrence rate and shorter DFS compared to stage IA counterparts.</p>

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Stage IA and IC adult granulosa cell tumors: Clinical features, long-term outcomes and prognostic factors in a 333-patient cohort over three decades

  • 期刊论文

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  • 发表日期：

    2025年10月14日

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  • Jingwen Gan,
  • Xiao Ma,
  • Ying Cao,
  • Dongyan Cao,
  • Huimei Zhou,
  • Mei Yu,
  • Tao Wang

摘要

Background

Adult granulosa cell tumors (AGCTs) are rare low-grade malignant ovarian tumors, with 80–90% diagnosed at FIGO stage I. This study aimed to identify prognostic factors and refine management for stage I AGCT.

Methods

In this 30-year retrospective cohort study, patients with stage I AGCT between January 1988 and January 2024 were selected and reviewed in total cohort and subgroups according to tumor stage.

Results

This retrospective study analyzed 333 eligible AGCT cases, including 196 patients (58.9%) with FIGO stage IA and 137 (41.1%) with stage IC. After a median follow-up of 138.5 ± 108.0 months, recurrence occurred in 55 patients (40.1%) in the IC group, significantly higher than that in the IA group (38 patients, 19.4%; P < 0.001, FDR = 0.005). Approximately half of recurrences in both groups were intra-abdominal, with comparable median recurrence intervals. Multivariate logistic regression identified stage IC (P = 0.001), incomplete staging surgery (P = 0.015) and adjuvant chemotherapy (P = 0.002) independent predictors of increased recurrence. In the propensity-matched cohort (n = 188), adjuvant chemotherapy showed no significant association with recurrence (P = 0.067). Cox multivariate analysis revealed stage IC and incomplete staging surgery as independent prognostic factors for worse DFS in early-stage disease (P = 0.001 and 0.012, respectively). Notably, complete staging surgery was associated with improved DFS specifically in stage IC patients (P = 0.016).

Conclusions

Unilateral salpingo-oophorectomy instead of simple cystectomy demonstrated a favorable safety profile in reproductive patients with stage I AGCT. Comprehensive surgical staging without lymphadenectomy should be considered as a viable treatment strategy, especially in the stage IC disease, manifesting a significantly higher recurrence rate and shorter DFS compared to stage IA counterparts.