Scholarlink

Background <p>Oligo-metastatic urothelial carcinoma (OMUC), characterized by a limited number of metastases, demonstrates better survival outcomes compared to poly-metastatic urothelial carcinoma (PMUC), but some patients with OMUC exhibit poor prognosis. However, a comprehensive analysis of prognostic factors in OMUC remains lacking. This study aimed to determine prognostic factors in patients with OMUC from a multicenter dataset and evaluate the effect of existing predictive models.</p> Methods <p>This retrospective study included 443 patients with metastatic urothelial carcinoma (MUC) from 15 institutions (YUSHIMA study). OMUC involved cases with three or fewer metastases. Clinical data were analyzed for associations with overall survival (OS) utilizing Cox regression models. The effect of existing predictive models (Bajorin, Bellmunt, and Apolo) on OMUC prognosis was evaluated.</p> Results <p>Patients with OMUC (n = 182) demonstrated better Eastern Cooperative Oncology Group–performance status (ECOG-PS) and lower visceral metastasis frequency compared to PMUC (n = 261). Patients with OMUC exhibited a median OS of 26.1 months <i>vs.</i> 13.7 months for PMUC (<i>p</i> &lt; 0.01). Poor ECOG-PS, liver metastasis, and hypoalbuminemia appeared as independent poor prognostic factors for OS in OMUC. The Bajorin, Bellmunt, and Apolo models significantly correlated with OS in patients with OMUC (<i>p</i> &lt; 0.01, for all).</p> Conclusion <p>Known prognostic factors for MUC were confirmed as significant prognostic factors for OS in OMUC, and existing prognostic models applied to OMUC. These results are expected to contribute to developing more effective treatment strategies for OMUC.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prognostic factors and effect of existing predictive models in oligo-metastatic urothelial carcinoma (YUSHIMA study)

  • 期刊论文

  • 发表日期：

    2025年4月21日

查看全文
  • Kenji Tanabe,
  • Soichiro Yoshida,
  • Tomoki Kimura,
  • Yuya Maezawa,
  • Kensaku Ishihara,
  • Naoki Inoue,
  • Keita Izumi,
  • Motohiro Fujiwara,
  • Masahiro Toide,
  • Takanobu Yamamoto,
  • Sho Uehara,
  • Saori Araki,
  • Masaharu Inoue,
  • Ryoji Takazawa,
  • Noboru Numao,
  • Yukihiro Ohtsuka,
  • Hajime Tanaka,
  • Yasuhisa Fujii

摘要

Background

Oligo-metastatic urothelial carcinoma (OMUC), characterized by a limited number of metastases, demonstrates better survival outcomes compared to poly-metastatic urothelial carcinoma (PMUC), but some patients with OMUC exhibit poor prognosis. However, a comprehensive analysis of prognostic factors in OMUC remains lacking. This study aimed to determine prognostic factors in patients with OMUC from a multicenter dataset and evaluate the effect of existing predictive models.

Methods

This retrospective study included 443 patients with metastatic urothelial carcinoma (MUC) from 15 institutions (YUSHIMA study). OMUC involved cases with three or fewer metastases. Clinical data were analyzed for associations with overall survival (OS) utilizing Cox regression models. The effect of existing predictive models (Bajorin, Bellmunt, and Apolo) on OMUC prognosis was evaluated.

Results

Patients with OMUC (n = 182) demonstrated better Eastern Cooperative Oncology Group–performance status (ECOG-PS) and lower visceral metastasis frequency compared to PMUC (n = 261). Patients with OMUC exhibited a median OS of 26.1 months vs. 13.7 months for PMUC (p < 0.01). Poor ECOG-PS, liver metastasis, and hypoalbuminemia appeared as independent poor prognostic factors for OS in OMUC. The Bajorin, Bellmunt, and Apolo models significantly correlated with OS in patients with OMUC (p < 0.01, for all).

Conclusion

Known prognostic factors for MUC were confirmed as significant prognostic factors for OS in OMUC, and existing prognostic models applied to OMUC. These results are expected to contribute to developing more effective treatment strategies for OMUC.