Effects of aging on complications following robot-assisted radical prostatectomy

期刊论文
发表日期：

2024年12月2日

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Shigeki Koterazawa,
Masashi Kubota,
Takayuki Sumiyoshi,
Ryoichi Saito,
Naoto Takaoka,
Yuto Hattori,
Yosuke Shimizu,
Toru Kanno,
Takeshi Soda,
Yoshiyuki Okada,
Kazunari Tsuchihashi,
Yuya Sekine,
Hiromitsu Negoro,
Ryoma Kurahashi,
Kimihiro Shimatani,
Atsuro Sawada,
Shusuke Akamatsu,
Takayuki Goto,
Takashi Kobayashi

摘要

Background

For prostate cancer (PCa) in the elderly, including patients ≥ 80 years, the safety of robot-assisted radical prostatectomy (RARP) is controversial. We aimed to evaluate the effect of aging on the postoperative complication rates after RARP.

Methods

This cohort study used a database of patients who had undergone RARP at 25 different institutes. We divided the cohort into four age groups (< 70, 70–74, 75–79, and ≥ 80 years). The complication rates after RARP in the 70–74, 75–79, and ≥ 80 year group were compared using the < 70 year group serving as the control group by applying the inverse probability of treatment weighting (IPTW)-adjusted regression analysis.

Results

A total of 8055 patients were evaluated. The postoperative complication rates were 8.8%, 9.7%, 9.6%, and 10.0% in the < 70, 71–74, 75–79, and ≥ 80 age groups, respectively. In IPTW-adjusted analyses, the risk of overall complications (< 70 vs. 70–74 year group: OR = 1.09 [95% CI 0.92–1.29]; < 70 vs. 75–79 year group: OR = 1.09 [95% CI 0.88–1.37], and < 70 vs. ≥ 80 year group: OR = 2.21 [95% CI 0.92–5.32]) did not change with increasing age. There was no significant increase in risk for any complication category, such as bowel dysfunction, symptomatic lymphocele, or bacterial infection, between the < 70 and ≥ 80 age groups.

Conclusion

Our findings showed that, in appropriately selected patients, the risk of complications after RARP did not increase with age, even at 75 or 80 years.