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<p>In this real-world study, we aim to investigate the relationship between NLR and the need for cerebrospinal fluid (CSF) diversion due to permanent hydrocephalus following tumor resection in children with posterior fossa tumors.We analyzed surveillance data on patients under 18 years of age with posterior fossa tumors who were treated at Zhujiang Hospital from January 2011 to September 2023. Patients were divided into two groups based on the initial postoperative NLR value: NLR &gt; 6 and NLR ≤ 6. The relationship between NLR and the need CSF diversion due to permanent hydrocephalus was evaluated using propensity score matching (PSM) and inverse probability weighting (IPW), with adjustments for baseline, preoperative, and postoperative clinical characteristics. A total of 210 patients were included in the study, with 104 in the NLR &gt; 6 group and 106 in the NLR ≤ 6 group. PSM identified 61 matched pairs for analysis. An initial postoperative NLR &gt; 6 was significantly associated with a higher risk of requiring permanent CSF diversion compared to an NLR ≤ 6 (34.4% vs. 13.1%; OR: 3.48, 95% CI: 1.40–8.66, <i>P</i> = 0.006). Furthermore, the results of the IPW analysis were consistent with PSM analysis. The ROC curve analysis demonstrates that the initial postoperative NLR has moderate discriminatory ability in predicting postoperative CSF diversion, with an AUC of 0.70. NLR is a reliable and practical biomarker for stratifying the risk of requiring CSF diversion in patients after posterior fossa tumor resection.</p>

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Neutrophil-to-lymphocyte ratio and the risk of cerebrospinal fluid diversion after posterior fossa tumor resection in pediatrics

  • 期刊论文

  • 发表日期：

    2026年3月27日

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  • Weitao Zhong,
  • Siyuan Lv,
  • Guanqiao Chen,
  • Weisong Li,
  • Zelin Li,
  • Qiang Wang,
  • Wangming Zhang

摘要

In this real-world study, we aim to investigate the relationship between NLR and the need for cerebrospinal fluid (CSF) diversion due to permanent hydrocephalus following tumor resection in children with posterior fossa tumors.We analyzed surveillance data on patients under 18 years of age with posterior fossa tumors who were treated at Zhujiang Hospital from January 2011 to September 2023. Patients were divided into two groups based on the initial postoperative NLR value: NLR > 6 and NLR ≤ 6. The relationship between NLR and the need CSF diversion due to permanent hydrocephalus was evaluated using propensity score matching (PSM) and inverse probability weighting (IPW), with adjustments for baseline, preoperative, and postoperative clinical characteristics. A total of 210 patients were included in the study, with 104 in the NLR > 6 group and 106 in the NLR ≤ 6 group. PSM identified 61 matched pairs for analysis. An initial postoperative NLR > 6 was significantly associated with a higher risk of requiring permanent CSF diversion compared to an NLR ≤ 6 (34.4% vs. 13.1%; OR: 3.48, 95% CI: 1.40–8.66, P = 0.006). Furthermore, the results of the IPW analysis were consistent with PSM analysis. The ROC curve analysis demonstrates that the initial postoperative NLR has moderate discriminatory ability in predicting postoperative CSF diversion, with an AUC of 0.70. NLR is a reliable and practical biomarker for stratifying the risk of requiring CSF diversion in patients after posterior fossa tumor resection.