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<p>To investigate the association between the preoperative triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, and the risk of postoperative seizures in adult patients undergoing elective craniotomy.&#xa0;This research is a retrospective cohort study that included adult patients who underwent craniotomy at West China Hospital from January 2011 to March 2021. The TyG index was calculated using preoperative fasting triglyceride and glucose levels. The optimal cutoff value (9.38) was determined via receiver operating characteristic (ROC) analysis, and patients were categorized into low and high TyG groups. The primary outcome was the occurrence of postoperative seizures during hospitalization. Multivariable logistic regression was used to assess the independent association between TyG index and postoperative seizures.&#xa0;A total of 11,024 patients were included in the analysis. Postoperative seizures occurred in 140 patients (1.27%). The incidence was significantly higher in the high TyG group compared with the low TyG group (1.9% vs. 1.2%, P = 0.037). In multivariable analysis, a TyG index &gt; 9.38 was independently associated with an increased risk of postoperative seizures (adjusted odds ratio [aOR]: 1.73; 95% confidence interval [CI]: 1.11–2.69; P = 0.015). Other independent risk factors included intraoperative blood transfusion (aOR: 2.18; 95% CI: 1.18–4.03) and malignant tumor pathology (aOR: 3.17; 95% CI: 1.89–5.29). Subgroup analyses revealed no significant interactions, suggesting a consistent association across clinical strata.&#xa0;An elevated preoperative TyG index is independently associated with an increased risk of postoperative seizures in patients undergoing elective craniotomy.</p>

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Elevated triglyceride-glucose index is a risk factor for postoperative seizures in adults undergoing elective craniotomy

  • 期刊论文

  • 发表日期：

    2025年10月16日

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  • Hourong Wang,
  • Yu Zhang ,
  • Jialing He ,
  • Yixin Tian ,
  • Peng Wang ,
  • Xin Chen ,
  • Yangchun Xiao ,
  • Fang Fang,
  • Lu Jia

摘要

To investigate the association between the preoperative triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, and the risk of postoperative seizures in adult patients undergoing elective craniotomy. This research is a retrospective cohort study that included adult patients who underwent craniotomy at West China Hospital from January 2011 to March 2021. The TyG index was calculated using preoperative fasting triglyceride and glucose levels. The optimal cutoff value (9.38) was determined via receiver operating characteristic (ROC) analysis, and patients were categorized into low and high TyG groups. The primary outcome was the occurrence of postoperative seizures during hospitalization. Multivariable logistic regression was used to assess the independent association between TyG index and postoperative seizures. A total of 11,024 patients were included in the analysis. Postoperative seizures occurred in 140 patients (1.27%). The incidence was significantly higher in the high TyG group compared with the low TyG group (1.9% vs. 1.2%, P = 0.037). In multivariable analysis, a TyG index > 9.38 was independently associated with an increased risk of postoperative seizures (adjusted odds ratio [aOR]: 1.73; 95% confidence interval [CI]: 1.11–2.69; P = 0.015). Other independent risk factors included intraoperative blood transfusion (aOR: 2.18; 95% CI: 1.18–4.03) and malignant tumor pathology (aOR: 3.17; 95% CI: 1.89–5.29). Subgroup analyses revealed no significant interactions, suggesting a consistent association across clinical strata. An elevated preoperative TyG index is independently associated with an increased risk of postoperative seizures in patients undergoing elective craniotomy.