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Background <p>Limited studies investigated the relationship between triglyceride-glucose (TyG) index and the rupture of intracranial aneurysm (IA). We aimed to examine the association between TyG index and IA rupture in patients diagnosed with IAs.</p> Materials and methods <p>Participants with IAs from January 2012 to April 2022 were retrospectively included. The association between TyG index and IA rupture was assessed by multivariable-adjusted logistic regression models, restricted cubic spline (RCS) models and subgroup analysis.</p> Results <p>Among 1535 patients with 1901 IAs, 596 (31.4%) IA rupture cases occurred. The incidence of IA rupture rose along with elevated TyG index. The positive correlation persisted after adjusting for age, sex, and other covariates, with adjusted odds ratios of 1.64 (95% CI 1.26–2.14) and 1.85 (95% CI 1.41–2.42) for TyG index tertiles 2 and 3. RCS curves showed a linear trend of TyG index with the risk of IA rupture. In the subgroup analysis, similar relationships were observed across subgroups defined by age, sex, hypertension, TC and aneurysm size.</p> Conclusions <p>There is a significant association between TyG index and the occurrence of IA rupture, indicating TyG index has the potential for risk assessment of IA rupture. Further prospective studies are warranted to validate its clinical utility.</p> Trial registration <p>ClinicalTrials.gov (NCT06456814). Registered on June 7, 2024.</p>

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Association between triglyceride-glucose index and intracranial aneurysm rupture: findings from a retrospective study

  • 期刊论文

  • 发表日期：

    2025年6月21日

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  • Jiancheng Lin,
  • Xin Feng,
  • Zhuohua Wen,
  • Chi Huang,
  • Mengshi Huang,
  • Jiwan Huang,
  • Runze Ge,
  • Anqi Xu,
  • Gengwu Ma,
  • Hongyu Shi,
  • Yuqi Hu,
  • Hao Yuan,
  • Can Li,
  • Ruizhe Yi,
  • Yuheng Jin,
  • Shuyin Liang,
  • Xin Zhang,
  • Xifeng Li,
  • Chuanzhi Duan

摘要

Background

Limited studies investigated the relationship between triglyceride-glucose (TyG) index and the rupture of intracranial aneurysm (IA). We aimed to examine the association between TyG index and IA rupture in patients diagnosed with IAs.

Materials and methods

Participants with IAs from January 2012 to April 2022 were retrospectively included. The association between TyG index and IA rupture was assessed by multivariable-adjusted logistic regression models, restricted cubic spline (RCS) models and subgroup analysis.

Results

Among 1535 patients with 1901 IAs, 596 (31.4%) IA rupture cases occurred. The incidence of IA rupture rose along with elevated TyG index. The positive correlation persisted after adjusting for age, sex, and other covariates, with adjusted odds ratios of 1.64 (95% CI 1.26–2.14) and 1.85 (95% CI 1.41–2.42) for TyG index tertiles 2 and 3. RCS curves showed a linear trend of TyG index with the risk of IA rupture. In the subgroup analysis, similar relationships were observed across subgroups defined by age, sex, hypertension, TC and aneurysm size.

Conclusions

There is a significant association between TyG index and the occurrence of IA rupture, indicating TyG index has the potential for risk assessment of IA rupture. Further prospective studies are warranted to validate its clinical utility.

Trial registration

ClinicalTrials.gov (NCT06456814). Registered on June 7, 2024.