Virtual anatomical atlas of the deep brain nuclei

This study aims to improve understanding of the anatomy of the deep brain nuclei relevant to deep brain stimulation as well as stereotactic lesioning procedures, including radio frequency, high-focused ultrasound, and radiosurgery. We created interactive, three-dimensional virtual models from cadaveric dissections and radiological segmentation. We used five brain specimens (ten hemispheres) obtained from routine autopsies, prepared according to Klingler’s method. Dissections were done from lateral to medial, medial to lateral, and superior to inferior to expose deep brain stimulation targets and adjacent structures. Using photogrammetry, we scanned the specimens to create detailed three-dimensional models. These models were uploaded to an online platform for free global access. Radiological models were also generated from atlas-based regions using the Montreal Neurological Institute template. We produced 16 high-quality cadaveric models at various stages of dissection. These and the radiological models were examined and interacted with through augmented reality and virtual reality headsets. This approach allowed comprehensive visual access to the anatomical structures and delineated their spatial relationships. These three-dimensional models provide detailed anatomical representations that can enhance anatomical orientiation, improve spatial perception, and serve as valuable educational tools for clinicians and students.