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<p>Whiteleg shrimp, <i>Penaeus vannamei</i>, is the most cultured shrimp species worldwide and plays an important role in global aquaculture production, food security, and economic growth. Nonetheless, infectious diseases, including acute hepatopancreatic necrosis disease (AHPND), can severely threaten the sustainability of shrimp production. These impacts may also be exacerbated by climate-related environmental stressors, such as temperature and salinity, which further disrupt host metabolism and immunity. Although many shrimp genes have been reported in AHPND studies, the molecular interactions underlying host responses to this disease remain unclear. Therefore, this study aims to investigate the potential molecular mechanisms of AHPND by identifying sets of interacting proteins and associated biological functions using network clustering. The <i>P. vannamei</i> AHPND-related proteins (<i>Pv</i>AHPNDrp) were identified via bibliomic analysis and used to construct the AHPND protein-protein interaction (PPI) network. The network was clustered using the DPClusO algorithm, and statistically enriched clusters were identified using the <i>Pv</i>AHPNDrp distribution. Functional enrichment analysis was subsequently performed to determine the potential biological functions associated with AHPND mechanisms. The analysis identified significant clusters with interactions of <i>Pv</i>AHPNDrp and non-<i>Pv</i>AHPNDrp, including glutamine-, proline-, and tyrosine-tRNA ligases, and alpha-1,4-N-acetylglucosaminyltransferase. Enriched biological functions, such as aminoacyl-tRNA ligase activity and lipid metabolic process, may be associated with <i>P. vannamei’s</i> response to AHPND. Collectively, this study provides a systems-level perspective on the molecular interaction networks associated with AHPND and identifies candidate proteins and functions for future experimental validation, contributing to improved understanding of disease mechanisms and supporting climate-resilient shrimp health management strategies.</p>

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Network Clustering Approach Reveals Key Proteins and Biological Functions in the Response of Whiteleg Shrimp (Penaeus vannamei) to Acute Hepatopancreatic Necrosis Disease

  • 期刊论文

  • 发表日期：

    2026年6月16日

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  • Noorul Darlina Edlin Abd Rahim,
  • Khor Waiho,
  • Min Pau Tan,
  • Yeong Yik Sung,
  • Md. Altaf-Ul-Amin,
  • Shigehiko Kanaya,
  • Zeti-Azura Mohamed-Hussein,
  • Nor Afiqah-Aleng

摘要

Whiteleg shrimp, Penaeus vannamei, is the most cultured shrimp species worldwide and plays an important role in global aquaculture production, food security, and economic growth. Nonetheless, infectious diseases, including acute hepatopancreatic necrosis disease (AHPND), can severely threaten the sustainability of shrimp production. These impacts may also be exacerbated by climate-related environmental stressors, such as temperature and salinity, which further disrupt host metabolism and immunity. Although many shrimp genes have been reported in AHPND studies, the molecular interactions underlying host responses to this disease remain unclear. Therefore, this study aims to investigate the potential molecular mechanisms of AHPND by identifying sets of interacting proteins and associated biological functions using network clustering. The P. vannamei AHPND-related proteins (PvAHPNDrp) were identified via bibliomic analysis and used to construct the AHPND protein-protein interaction (PPI) network. The network was clustered using the DPClusO algorithm, and statistically enriched clusters were identified using the PvAHPNDrp distribution. Functional enrichment analysis was subsequently performed to determine the potential biological functions associated with AHPND mechanisms. The analysis identified significant clusters with interactions of PvAHPNDrp and non-PvAHPNDrp, including glutamine-, proline-, and tyrosine-tRNA ligases, and alpha-1,4-N-acetylglucosaminyltransferase. Enriched biological functions, such as aminoacyl-tRNA ligase activity and lipid metabolic process, may be associated with P. vannamei’s response to AHPND. Collectively, this study provides a systems-level perspective on the molecular interaction networks associated with AHPND and identifies candidate proteins and functions for future experimental validation, contributing to improved understanding of disease mechanisms and supporting climate-resilient shrimp health management strategies.