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<p><i>Aeromonas hydrophila</i> is an important etiologic agent that can pose a significant threat to the health of aquatic animals. Nonetheless, the immunometabolic crosstalk of hybrid crucian carp (WR, <i>Carassius cuvieri</i>♀ × <i>Carassius auratus</i> red var♂) after gut infection remains largely understudied. In this study, WRs receiving gut infection with <i>A. hydrophila</i> L3-3 displayed increased levels of tissue damage and antioxidant collapse. Then, multiomics analyses indicated that fatty acid metabolism may be considered as the crucial metabolic pathways in midgut of WRs following gut infection with <i>A. hydrophila</i> L3-3, with FFA(14:1) and Ser-Ile-Asn-Lys acting as pivotal biomarkers. These findings may clarify the immunometabolic response and identify the molecular regulatory mechanisms in gut tract of WRs after <i>A. hydrophila</i> L3-3 infection.</p>

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Integrated Transcriptomic and Metabolomic Analyses Reveal Molecular Mechanism in Hybrid Crucian Carp (Carassius cuvieri♀ × Carassius auratus Red var♂) after Gut Infection with Aeromonas hydrophila L3-3

  • 期刊论文

  • 发表日期：

    2026年2月10日

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  • Fei Wang,
  • Wei-Sheng Luo,
  • Zi-Le Qin,
  • Jian Li,
  • Si-Ze Xiao,
  • Sheng-Wei Luo

摘要

Aeromonas hydrophila is an important etiologic agent that can pose a significant threat to the health of aquatic animals. Nonetheless, the immunometabolic crosstalk of hybrid crucian carp (WR, Carassius cuvieri♀ × Carassius auratus red var♂) after gut infection remains largely understudied. In this study, WRs receiving gut infection with A. hydrophila L3-3 displayed increased levels of tissue damage and antioxidant collapse. Then, multiomics analyses indicated that fatty acid metabolism may be considered as the crucial metabolic pathways in midgut of WRs following gut infection with A. hydrophila L3-3, with FFA(14:1) and Ser-Ile-Asn-Lys acting as pivotal biomarkers. These findings may clarify the immunometabolic response and identify the molecular regulatory mechanisms in gut tract of WRs after A. hydrophila L3-3 infection.