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Background <p>healthcare workers who carry methicillin-resistant and vancomycin-resistant <i>staphylococcus aureus</i> pathogens in their nasal passage serves as a significant reservoir for the transmission of these resistant pathogens to patients, especially those with weakened immune systems. In Ethiopia, particularly in the study area, there is a lack of sufficient data on the prevalence of MRSA and VRSA among healthcare personnel. Therefore, this study was designed to investigate the rate of nasal carriage of methicillin- and vancomycin-resistant <i>Staphylococcus aureus</i> among healthcare workers.</p> Objective <p>This study aimed to assess the nasal carriage rate of methicillin-resistant and vancomycin-resistant <i>staphylococcus aureus</i>, as well as their antibiotic susceptibility pattern among healthcare workers at Jigjiga University Sheik Hassen Yebare Comprehensive Specialized Hospital, Jigjiga, Ethiopia.</p> Materials and methods <p>A hospital-based cross-sectional study was carried out at Jigjiga University Sheik Hassen Yebare Comprehensive Specialized Hospital over a three-month period, from May to July 2024. A total of 178 healthcare professionals working in various wards were enrolled using a convenient sampling method. Nasal swab samples were collected and cultured on Blood Agar and Mannitol Salt Agar, followed by incubation at 37&#xa0;°C for 24&#xa0;h. Bacterial identification and antimicrobial susceptibility testing were performed using the automated VITEK 2 Compact system.</p> Result <p>The nasal carriage rate of <i>staphylococcus aureus</i> and methicillin resistance <i>staphylococcus aureus</i> among health care workers was 21.9% (95% CI: 18.3–27.7%) and 71.8% (95%CI: 65.1–75.1%), respectively. Five (17.9%) inducible clindamycin resistance and two (5.1%) vancomycin resistance <i>staphylococcus aureus</i> isolates were also detected. Linezolid, Tigecycline, Vancomycin and Teicoplanin were the most effective antibiotic for both methicillin sensitive and methicillin resistance <i>staphylococcus aureus</i>. The overall prevalence of muti-drug resistance isolates was 41.3% (95% CI: 35.7–46.3%).</p> Conclusions and recommendations <p>The high rate of methicillin resistance staphylococcus aureus carriage among health care workers is concerning and highlights the need for a further, more comprehensive study. Implementing regular screening of health care personnel is crucial to effectively control and prevent the spread of methicillin resistance <i>staphylococcus aureus</i>.</p>

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Methicillin and Vancomycin resistance Staphylococcus aureus nasal carriage rate and antimicrobial susceptibility pattern among health care workers at Jigjiga university sheik Hassen Yebare comprehensive specialized Hospital, Jigjiga, Ethiopia

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  • 发表日期：

    2026年2月10日

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  • Sara Tesfaye,
  • Shamil Barsenga,
  • Surafel Mekuria,
  • Addisu Tesfaye,
  • Bawlah Tahir,
  • Gedlegebriel Fikadu

摘要

Background

healthcare workers who carry methicillin-resistant and vancomycin-resistant staphylococcus aureus pathogens in their nasal passage serves as a significant reservoir for the transmission of these resistant pathogens to patients, especially those with weakened immune systems. In Ethiopia, particularly in the study area, there is a lack of sufficient data on the prevalence of MRSA and VRSA among healthcare personnel. Therefore, this study was designed to investigate the rate of nasal carriage of methicillin- and vancomycin-resistant Staphylococcus aureus among healthcare workers.

Objective

This study aimed to assess the nasal carriage rate of methicillin-resistant and vancomycin-resistant staphylococcus aureus, as well as their antibiotic susceptibility pattern among healthcare workers at Jigjiga University Sheik Hassen Yebare Comprehensive Specialized Hospital, Jigjiga, Ethiopia.

Materials and methods

A hospital-based cross-sectional study was carried out at Jigjiga University Sheik Hassen Yebare Comprehensive Specialized Hospital over a three-month period, from May to July 2024. A total of 178 healthcare professionals working in various wards were enrolled using a convenient sampling method. Nasal swab samples were collected and cultured on Blood Agar and Mannitol Salt Agar, followed by incubation at 37 °C for 24 h. Bacterial identification and antimicrobial susceptibility testing were performed using the automated VITEK 2 Compact system.

Result

The nasal carriage rate of staphylococcus aureus and methicillin resistance staphylococcus aureus among health care workers was 21.9% (95% CI: 18.3–27.7%) and 71.8% (95%CI: 65.1–75.1%), respectively. Five (17.9%) inducible clindamycin resistance and two (5.1%) vancomycin resistance staphylococcus aureus isolates were also detected. Linezolid, Tigecycline, Vancomycin and Teicoplanin were the most effective antibiotic for both methicillin sensitive and methicillin resistance staphylococcus aureus. The overall prevalence of muti-drug resistance isolates was 41.3% (95% CI: 35.7–46.3%).

Conclusions and recommendations

The high rate of methicillin resistance staphylococcus aureus carriage among health care workers is concerning and highlights the need for a further, more comprehensive study. Implementing regular screening of health care personnel is crucial to effectively control and prevent the spread of methicillin resistance staphylococcus aureus.