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<p>To combat the issue of pathogenic infections, the current work successfully synthesized a nanocomposite, which is based on the aqueous extract of <i>Alkanna tinctoria</i> (ATE) and silver-zinc oxide nanoparticles (ATE@Ag-ZnO NPs), using a green technique. Analytical methods were used to characterize the synthesized nanocomposite to verify its size, shape, distribution, surface charge, and crystallinity. The resulting nanocomposite created permanent colloidal nano-solutions, demonstrated excellent dispersion, and appeared at the nanoscale. The antimicrobial, antifungal, and antibiofilm characteristics of the ATE@Ag-ZnO nanocomposite were assessed. For every studied microbial strain, the ATE@Ag-ZnO nanocomposite’s minimum inhibitory concentration (MIC) was determined. The encouraging findings showed that the MIC range of ATE@Ag-ZnO against all strains was 250–31.25&#xa0;µg/mL. It demonstrated promise against <i>S. epidermidis</i> and <i>A. calcoaceticus</i>, with a MIC of 31.25&#xa0;µg/mL. Furthermore, with inhibition zones of 22.0, 20.0, and 15.0&#xa0;mm, respectively, the ATE@Ag-ZnO nanocomposite demonstrated antibacterial efficacy against gram-positive bacteria <i>A. calcoaceticus</i>, <i>S. epidermidis</i>, and <i>C. tropicalis</i> at 250&#xa0;µg/mL. The highest percentage of inhibition (91.44%) was seen in <i>S. aureus</i> treated with 250&#xa0;µg/mL ATE@Ag-ZnO nanocomposite, followed by <i>A. calcoaceticus</i> (68.83%) and <i>C. albicans</i> (64.81%). In conclusion, we successfully created the green synthesized ATE@Ag-ZnO nanocomposite, which demonstrated promising antibacterial, antifungal, and antibiofilm agents against some pathogenic microbes.</p>

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Alkanna tinctoria extract-mediated biomass synthesis of Ag-ZnO nanoparticles: characterization, antimicrobial and antibiofilm activities

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • Widad M. Al-Bishri,
  • Roqayah Saleh Al-Habeeb

摘要

To combat the issue of pathogenic infections, the current work successfully synthesized a nanocomposite, which is based on the aqueous extract of Alkanna tinctoria (ATE) and silver-zinc oxide nanoparticles (ATE@Ag-ZnO NPs), using a green technique. Analytical methods were used to characterize the synthesized nanocomposite to verify its size, shape, distribution, surface charge, and crystallinity. The resulting nanocomposite created permanent colloidal nano-solutions, demonstrated excellent dispersion, and appeared at the nanoscale. The antimicrobial, antifungal, and antibiofilm characteristics of the ATE@Ag-ZnO nanocomposite were assessed. For every studied microbial strain, the ATE@Ag-ZnO nanocomposite’s minimum inhibitory concentration (MIC) was determined. The encouraging findings showed that the MIC range of ATE@Ag-ZnO against all strains was 250–31.25 µg/mL. It demonstrated promise against S. epidermidis and A. calcoaceticus, with a MIC of 31.25 µg/mL. Furthermore, with inhibition zones of 22.0, 20.0, and 15.0 mm, respectively, the ATE@Ag-ZnO nanocomposite demonstrated antibacterial efficacy against gram-positive bacteria A. calcoaceticus, S. epidermidis, and C. tropicalis at 250 µg/mL. The highest percentage of inhibition (91.44%) was seen in S. aureus treated with 250 µg/mL ATE@Ag-ZnO nanocomposite, followed by A. calcoaceticus (68.83%) and C. albicans (64.81%). In conclusion, we successfully created the green synthesized ATE@Ag-ZnO nanocomposite, which demonstrated promising antibacterial, antifungal, and antibiofilm agents against some pathogenic microbes.