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<p>This study aimed to develop a selenium nanoparticles (SeNPs)-enriched probiotic strain with potential anti-hangover effects. <i>Pediococcus acidilactici</i> JW-015 was screened for its high tolerance to inorganic selenium (up to 80&#xa0;mM sodium selenite) and efficient synthesis of SeNPs, achieving a selenium accumulation concentration of 6974 ± 90.71&#xa0;μg/g, with SeNPs accounting for 86.54% ± 2.48%. Safety and probiotic properties were evaluated, confirming that JW-015 is a safe probiotic strain and that selenium enrichment enhanced its probiotic properties. Furthermore, JW-015 demonstrated significant anti-hangover efficacy, with selenium enrichment improving the oxidative stress capacity, alcohol tolerance, alcohol degradation ability, and relevant enzyme activities (ADH and ALDH) of the strain. This study provides a promising bio-carrier for SeNPs transformation and expands the applications of selenium-enriched LAB.</p>

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Screening, characterization, and potential anti-hangover ability of selenium nanoparticle-enriched lactobacillus

  • 期刊论文

  • 发表日期：

    2025年3月28日

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  • Jie Gao,
  • Shuoqi Jiang,
  • Zehao Li,
  • Shoufeng Liu,
  • Qiuya Gu,
  • Xiaobin Yu

摘要

This study aimed to develop a selenium nanoparticles (SeNPs)-enriched probiotic strain with potential anti-hangover effects. Pediococcus acidilactici JW-015 was screened for its high tolerance to inorganic selenium (up to 80 mM sodium selenite) and efficient synthesis of SeNPs, achieving a selenium accumulation concentration of 6974 ± 90.71 μg/g, with SeNPs accounting for 86.54% ± 2.48%. Safety and probiotic properties were evaluated, confirming that JW-015 is a safe probiotic strain and that selenium enrichment enhanced its probiotic properties. Furthermore, JW-015 demonstrated significant anti-hangover efficacy, with selenium enrichment improving the oxidative stress capacity, alcohol tolerance, alcohol degradation ability, and relevant enzyme activities (ADH and ALDH) of the strain. This study provides a promising bio-carrier for SeNPs transformation and expands the applications of selenium-enriched LAB.