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Background <p>Papillary adenocarcinoma (Pap) is a relatively rare histological subtype of differentiated adenocarcinoma, and its biological behavior has not been fully elucidated. The present study aimed to clarify the clinicopathological characteristics of Pap.</p> Methods <p>This study retrospectively included 1701 patients with differentiated-type gastric cancer who underwent gastrectomy at our institution between 2009 and 2021. Clinicopathological characteristics, recurrence patterns, and survival outcomes were compared between the two groups.</p> Results <p>Patients in the Pap group were older and showed higher rates of venous—and lymphatic invasion, as well as more advanced clinical and pathological stages. In the multivariate analysis of cumulative recurrence, histological type was identified as an independent predictor (HR 2.051, <i>p</i> = 0.037). The most common initial site of recurrence was the liver in both groups, with a significantly higher incidence observed in the Pap group (<i>p</i> &lt; 0.001). In the multivariate analysis of overall survival, histological type was also identified as an independent prognostic factor (HR 1.962, <i>p</i> = 0.044).</p> Conclusions <p>Pap showed poorer survival than the Tub group, with a particularly higher incidence of liver metastasis recurrence.</p>

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Clinicopathological characteristics of gastric papillary adenocarcinoma compared with tubular adenocarcinoma

  • 期刊论文

  • 发表日期：

    2026年6月24日

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  • Taku Hattori,
  • Masanori Terashima,
  • Atsushi Ochiai,
  • Tadakazu Shimoda,
  • Yusuke Koseki,
  • Kenichiro Furukawa,
  • Keiichi Fujiya,
  • Yutaka Tanizawa,
  • Etsuro Bando

摘要

Background

Papillary adenocarcinoma (Pap) is a relatively rare histological subtype of differentiated adenocarcinoma, and its biological behavior has not been fully elucidated. The present study aimed to clarify the clinicopathological characteristics of Pap.

Methods

This study retrospectively included 1701 patients with differentiated-type gastric cancer who underwent gastrectomy at our institution between 2009 and 2021. Clinicopathological characteristics, recurrence patterns, and survival outcomes were compared between the two groups.

Results

Patients in the Pap group were older and showed higher rates of venous—and lymphatic invasion, as well as more advanced clinical and pathological stages. In the multivariate analysis of cumulative recurrence, histological type was identified as an independent predictor (HR 2.051, p = 0.037). The most common initial site of recurrence was the liver in both groups, with a significantly higher incidence observed in the Pap group (p < 0.001). In the multivariate analysis of overall survival, histological type was also identified as an independent prognostic factor (HR 1.962, p = 0.044).

Conclusions

Pap showed poorer survival than the Tub group, with a particularly higher incidence of liver metastasis recurrence.