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Background <p>Minimally invasive surgery (MIS) is increasingly used for gastric cancer; however, its application to remnant gastric cancer (RGC) remains technically challenging due to adhesions and altered anatomy. Large-scale comparative data on the safety and effectiveness of MIS versus open surgery for RGC are limited. This retrospective study aimed to evaluate the short-term outcomes of MIS versus open completion total gastrectomy for RGC.</p> Methods <p>We retrospectively analyzed data from 3337 patients who underwent completion total gastrectomy for RGC between January 2018 and December 2022 using the National Clinical Database of Japan. After applying predefined inclusion criteria, we performed one-to-one propensity score matching to balance baseline characteristics between the MIS and open surgery groups and compared short-term surgical outcomes.</p> Results <p>After matching, 540 patient pairs were included in the analysis. MIS was associated with a significantly longer operative time (median 344 vs. 248.5&#xa0;min; <i>P</i> &lt; 0.001) but reduced blood loss (median 70 vs. 290&#xa0;mL; <i>P</i> &lt; 0.001). The incidence of anastomotic leakage was higher in the MIS group (9.8% vs. 6.3%; <i>P</i> = 0.034). Postoperative hospital stay was numerically shorter in the MIS group (median 13 vs. 14&#xa0;days; <i>P</i> = 0.065). Overall complication, reoperation, and mortality rates were comparable between groups.</p> Conclusions <p>MIS for RGC showed comparable short-term outcomes to those of open surgery in a nationwide analysis, with advantages including reduced blood loss. However, the increased risk of anastomotic leakage highlights the need for careful patient selection and ongoing technical refinement.</p>

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Minimally invasive versus open completion total gastrectomy for remnant gastric cancer: a nationwide propensity score-matched analysis

  • 期刊论文

  • 发表日期：

    2025年9月22日

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  • Nobuhiro Nakazawa,
  • Takashi Sakamoto,
  • Hiroyuki Yamamoto,
  • Akihiko Sano,
  • Makoto Sakai,
  • Shingo Kanaji,
  • Hirotoshi Kikuchi,
  • Hideki Ueno,
  • Ken Shirabe,
  • Hiroshi Saeki

摘要

Background

Minimally invasive surgery (MIS) is increasingly used for gastric cancer; however, its application to remnant gastric cancer (RGC) remains technically challenging due to adhesions and altered anatomy. Large-scale comparative data on the safety and effectiveness of MIS versus open surgery for RGC are limited. This retrospective study aimed to evaluate the short-term outcomes of MIS versus open completion total gastrectomy for RGC.

Methods

We retrospectively analyzed data from 3337 patients who underwent completion total gastrectomy for RGC between January 2018 and December 2022 using the National Clinical Database of Japan. After applying predefined inclusion criteria, we performed one-to-one propensity score matching to balance baseline characteristics between the MIS and open surgery groups and compared short-term surgical outcomes.

Results

After matching, 540 patient pairs were included in the analysis. MIS was associated with a significantly longer operative time (median 344 vs. 248.5 min; P < 0.001) but reduced blood loss (median 70 vs. 290 mL; P < 0.001). The incidence of anastomotic leakage was higher in the MIS group (9.8% vs. 6.3%; P = 0.034). Postoperative hospital stay was numerically shorter in the MIS group (median 13 vs. 14 days; P = 0.065). Overall complication, reoperation, and mortality rates were comparable between groups.

Conclusions

MIS for RGC showed comparable short-term outcomes to those of open surgery in a nationwide analysis, with advantages including reduced blood loss. However, the increased risk of anastomotic leakage highlights the need for careful patient selection and ongoing technical refinement.