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Background <p>Chronic atrophic gastritis, represented by <i>Helicobacter pylori</i> (<i>H. pylori</i>) or autoimmune gastritis (AIG), has been recognized as a risk factor for gastric carcinoma (GC). Differences in the clinicopathological features of GC with AIG (GC–AIG) based on <i>H. pylori</i> infection status remain unclear.</p> Methods <p>This retrospective analysis included 65 cases of GC–AIG in which endoscopic resection or gastrectomy was performed at a single center between 2008 and 2024. The cases were categorized into Group A (<i>H. pylori</i>-naïve GC–AIG) or Group B (<i>H. pylori</i>-infected GC–AIG), and the clinical and pathological data were compared between the groups.</p> Results <p>Group A included 18 cases with 25 lesions and Group B included 47 cases with 72 lesions. The median age [interquartile range] was significantly younger in Group A (70 [63–74] years) than in Group B (75 [62–79] years, <i>p</i> = 0.045). Tumors in Group A were more frequently located in the upper and middle stomach, whereas those in Group B were predominantly located in the lower stomach (<i>p</i> = 0.006). Group A had a significantly higher proportion of pure undifferentiated-type adenocarcinoma (Laurén’s diffuse type) than Group B (28.0% versus 8.3%, <i>p</i> = 0.027).</p> Conclusions <p><i>H. pylori</i>-naïve GC–AIG is characterized by younger age, a higher prevalence of pure undifferentiated-type adenocarcinoma, and tumors predominantly located in the upper and middle stomach.</p>

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Comparison of clinicopathological features of gastric carcinoma in autoimmune gastritis with and without Helicobacter pylori infection

  • 期刊论文

  • 发表日期：

    2025年7月25日

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  • Ayaka Takasu,
  • Toshiaki Hirasawa,
  • Yuka Higashi,
  • Kaoru Nakano,
  • Souya Nunobe,
  • Takuji Gotoda,
  • Hiroshi Kawachi

摘要

Background

Chronic atrophic gastritis, represented by Helicobacter pylori (H. pylori) or autoimmune gastritis (AIG), has been recognized as a risk factor for gastric carcinoma (GC). Differences in the clinicopathological features of GC with AIG (GC–AIG) based on H. pylori infection status remain unclear.

Methods

This retrospective analysis included 65 cases of GC–AIG in which endoscopic resection or gastrectomy was performed at a single center between 2008 and 2024. The cases were categorized into Group A (H. pylori-naïve GC–AIG) or Group B (H. pylori-infected GC–AIG), and the clinical and pathological data were compared between the groups.

Results

Group A included 18 cases with 25 lesions and Group B included 47 cases with 72 lesions. The median age [interquartile range] was significantly younger in Group A (70 [63–74] years) than in Group B (75 [62–79] years, p = 0.045). Tumors in Group A were more frequently located in the upper and middle stomach, whereas those in Group B were predominantly located in the lower stomach (p = 0.006). Group A had a significantly higher proportion of pure undifferentiated-type adenocarcinoma (Laurén’s diffuse type) than Group B (28.0% versus 8.3%, p = 0.027).

Conclusions

H. pylori-naïve GC–AIG is characterized by younger age, a higher prevalence of pure undifferentiated-type adenocarcinoma, and tumors predominantly located in the upper and middle stomach.