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Background <p>Gastric cancer (GC) presents challenges in predicting treatment responses due to its patient-specific heterogeneity. Recently, liquid biopsies have emerged as a valuable data modality, offering essential cellular and molecular insights while facilitating the capture of time-sensitive information. This study aimed to leverage artificial intelligence (AI) technology to analyze longitudinal liquid biopsy data. </p> Methods <p>We collected a dataset from longitudinal liquid biopsies of 91 patients at Peking Cancer Hospital, spanning from July 2019 to April 2022. This dataset included 1895 tumor-related cellular images and 1698 tumor marker indices. Subsequently, we introduced the Dynamic-Aware Model (DAM) to predict responses to GC treatment. DAM incorporates dynamic data through AI-engineered components, facilitating an in-depth longitudinal analysis.</p> Results <p>Utilizing threefold cross-validation, DAM exhibited superior performance compared to traditional cell-counting methods, achieving an AUC of 0.807 in predicting GC treatment responses. In the test set, DAM maintained stable efficacy with an AUC of 0.802. Besides, DAM showed the capability to accurately predict treatment responses based on early treatment data. Moreover, DAM’s visual analysis of attention mechanisms identified six dynamic visual features related to focus areas, which were strongly associated with treatment-response.</p> Conclusions <p>These findings represent a pioneering effort in applying AI technology to interpret longitudinal liquid biopsy data and employ visual analytics in GC. This approach provides a promising pathway toward precise response prediction and personalized treatment strategies for patients with GC.</p>

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Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月17日

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  • Zifan Chen,
  • Jie Zhao,
  • Yanyan Li,
  • Xujiao Feng,
  • Yang Chen,
  • Yilin Li,
  • Xinyu Nan,
  • Huimin Liu,
  • Bin Dong,
  • Lin Shen,
  • Li Zhang

摘要

Background

Gastric cancer (GC) presents challenges in predicting treatment responses due to its patient-specific heterogeneity. Recently, liquid biopsies have emerged as a valuable data modality, offering essential cellular and molecular insights while facilitating the capture of time-sensitive information. This study aimed to leverage artificial intelligence (AI) technology to analyze longitudinal liquid biopsy data.

Methods

We collected a dataset from longitudinal liquid biopsies of 91 patients at Peking Cancer Hospital, spanning from July 2019 to April 2022. This dataset included 1895 tumor-related cellular images and 1698 tumor marker indices. Subsequently, we introduced the Dynamic-Aware Model (DAM) to predict responses to GC treatment. DAM incorporates dynamic data through AI-engineered components, facilitating an in-depth longitudinal analysis.

Results

Utilizing threefold cross-validation, DAM exhibited superior performance compared to traditional cell-counting methods, achieving an AUC of 0.807 in predicting GC treatment responses. In the test set, DAM maintained stable efficacy with an AUC of 0.802. Besides, DAM showed the capability to accurately predict treatment responses based on early treatment data. Moreover, DAM’s visual analysis of attention mechanisms identified six dynamic visual features related to focus areas, which were strongly associated with treatment-response.

Conclusions

These findings represent a pioneering effort in applying AI technology to interpret longitudinal liquid biopsy data and employ visual analytics in GC. This approach provides a promising pathway toward precise response prediction and personalized treatment strategies for patients with GC.