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Background <p>Loss of appetite following gastric cancer surgery, particularly total gastrectomy, significantly impacts patient quality of life due to the removal of the ghrelin-secreting region. We developed appetite-preserving gastrectomy (APG), a modified total gastrectomy that preserves this region.</p> Methods <p>Ten consecutive patients with esophagogastric junction cancer who were indicated for total gastrectomy and underwent APG between April 2023 and April 2024 were evaluated for early surgical outcomes, appetite, and changes in weight and body composition.</p> Results <p>There were no postoperative complications of grade II or higher (Clavien–Dindo classification). Appetite, assessed using the Simplified Nutritional Appetite Questionnaire, showed no significant impairment at 3&#xa0;months (14.5 points, <i>P</i> = 0.82) and 6&#xa0;months (15 points, <i>P</i> = 0.44) postoperatively compared with preoperative values. Oral calorie intake was maintained at 3&#xa0;months (1675&#xa0;kcal, <i>P</i> = 0.97) and 6&#xa0;months (1675&#xa0;kcal, <i>P</i> = 0.22) postoperatively compared with preoperative levels. The patients’ body weight decreased by 9.2% at 6&#xa0;months postoperatively compared with preoperative values, but their lean body mass remained stable. Although a significant decrease in the blood Ghrelin levels was observed postoperatively, 53% and 60.4% of the preoperative levels was maintained at one month and 6&#xa0;months, respectively.</p> Conclusions <p>APG is a safe procedure that preserves the residual stomach as an endocrine organ, maintains ghrelin secretion and appetite, and prevents muscle loss. However, further trials are required to compare the efficacy of APG with total gastrectomy in preventing postoperative appetite loss.</p>

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Appetite-preserving gastrectomy (APG) for esophagogastric junction cancer: preserving the residual stomach as an endocrine organ

  • 期刊论文

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  • 发表日期：

    2025年3月18日

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  • Naoki Hiki,
  • Tadashi Higuchi,
  • Koshi Kumagai,
  • Kota Okuno,
  • Hiroyuki Minoura,
  • Yumi Sato,
  • Shohei Fujita,
  • Hiroki Harada,
  • Motohiro Chuman,
  • Marie Washio,
  • Mikiko Sakuraya,
  • Masahiro Niihara,
  • Yusuke Kumamoto,
  • Takeshi Naitoh,
  • Keishi Yamashita

摘要

Background

Loss of appetite following gastric cancer surgery, particularly total gastrectomy, significantly impacts patient quality of life due to the removal of the ghrelin-secreting region. We developed appetite-preserving gastrectomy (APG), a modified total gastrectomy that preserves this region.

Methods

Ten consecutive patients with esophagogastric junction cancer who were indicated for total gastrectomy and underwent APG between April 2023 and April 2024 were evaluated for early surgical outcomes, appetite, and changes in weight and body composition.

Results

There were no postoperative complications of grade II or higher (Clavien–Dindo classification). Appetite, assessed using the Simplified Nutritional Appetite Questionnaire, showed no significant impairment at 3 months (14.5 points, P = 0.82) and 6 months (15 points, P = 0.44) postoperatively compared with preoperative values. Oral calorie intake was maintained at 3 months (1675 kcal, P = 0.97) and 6 months (1675 kcal, P = 0.22) postoperatively compared with preoperative levels. The patients’ body weight decreased by 9.2% at 6 months postoperatively compared with preoperative values, but their lean body mass remained stable. Although a significant decrease in the blood Ghrelin levels was observed postoperatively, 53% and 60.4% of the preoperative levels was maintained at one month and 6 months, respectively.

Conclusions

APG is a safe procedure that preserves the residual stomach as an endocrine organ, maintains ghrelin secretion and appetite, and prevents muscle loss. However, further trials are required to compare the efficacy of APG with total gastrectomy in preventing postoperative appetite loss.