<p>Traditional acrylate reactive diluents, which are derived from fossil resources, are known to exhibit significant irritation and allergenic potential, leading to their prohibition in high-end electronics, particularly in wearable devices. To address these limitations, four bio-based acrylate reactive diluents (BRDs) were synthesized <i>via</i> the reaction of alcohols derived from renewable sources, piperitol, vanillin, eugenol, and isosorbide, with methacrylic anhydride. The viscosity of the synthesized BRDs and the <i>T</i>_g of their corresponding polymers were systematically evaluated and compared with those of the petroleum-based diluent isobornyl acrylate (IBOA). The BRDs were then blended with acrylate-terminated polyurethane (APU) to formulate a series of UV-curable polyurethane adhesives (APU-BRDs). The results suggest that BRDs effectively reduce the viscosity of APU. By selecting and combining BRDs, the bonding strength of APU-BRDs to polar substrates such as PC and glass can reach 20 MPa. Even for non-polar substrates like PE, the strength is close to 5 MPa. The values obtained in this study exceed those of adhesives prepared using the conventional petroleum-based diluent IBOA. Furthermore, the study explored the potential application of APU-BRDs in smart wearable devices, confirming their suitability for next-generation wearable technology.</p>