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<p>Direct ink writing (DIW) has emerged as one of the most promising approaches for biomedical application, owing to its broad material compatibility, ease of operation, and high-resolution. However, the development of DIW inks with suitable rheological properties and excellent biocompatibility remains a significant challenge. Herein, an acrylate-functionalized liquid poly(4-methyl-<i>ε</i>-caprolactone) (PMCLDA) was synthesized as the precursor of 3D printing ink, accompanied with thiol-functionalized polyethylene glycol (PEGSH) as a rheological modifier. It was indicated from rheology study that the incorporation of PEGSH with PMCLDA precursor afforded the mixt inks shear thinning behavior. Moreover, it was verified by <i>in situ</i> Fourier transform infrared spectroscopy and photo-rheology that the mixed ink could rapidly cure through thiol-acrylate crosslinking under UV light. Various inks formulations were successfully utilized for printing 3D scaffolds <i>via</i> UV-assisted DIW, with the optimized printability for SH75 ink. Moreover, the 3D-printed scaffolds exhibited excellent elasticity and degradability. <i>In vitro</i> cytocompatibility assessments showed that the scaffolds exhibited good cytocompatibility and supported the proliferation of L929 mouse fibroblasts for a duration of 7 days. Therefore, it is demonstrated that the 3D-printed scaffolds crosslinked <i>via</i> thiol-acrylate crosslinking have great potential for applications in tissue engineering.</p>

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Direct Ink Writing of Biodegradable Elastic Scaffolds via Rapid Thiol-Acrylate Photocrosslinking

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Xiao-Yu Li,
  • Chong-Guang Li,
  • Kai Chen,
  • Yan Xiao,
  • Xin-Xin Li,
  • Mei-Dong Lang

摘要

Direct ink writing (DIW) has emerged as one of the most promising approaches for biomedical application, owing to its broad material compatibility, ease of operation, and high-resolution. However, the development of DIW inks with suitable rheological properties and excellent biocompatibility remains a significant challenge. Herein, an acrylate-functionalized liquid poly(4-methyl-ε-caprolactone) (PMCLDA) was synthesized as the precursor of 3D printing ink, accompanied with thiol-functionalized polyethylene glycol (PEGSH) as a rheological modifier. It was indicated from rheology study that the incorporation of PEGSH with PMCLDA precursor afforded the mixt inks shear thinning behavior. Moreover, it was verified by in situ Fourier transform infrared spectroscopy and photo-rheology that the mixed ink could rapidly cure through thiol-acrylate crosslinking under UV light. Various inks formulations were successfully utilized for printing 3D scaffolds via UV-assisted DIW, with the optimized printability for SH75 ink. Moreover, the 3D-printed scaffolds exhibited excellent elasticity and degradability. In vitro cytocompatibility assessments showed that the scaffolds exhibited good cytocompatibility and supported the proliferation of L929 mouse fibroblasts for a duration of 7 days. Therefore, it is demonstrated that the 3D-printed scaffolds crosslinked via thiol-acrylate crosslinking have great potential for applications in tissue engineering.