<p>Smart pesticide delivery systems based on stimuli-responsive nanocarriers have attracted considerable attention because of their potential to enhance pesticide efficiency while reducing environmental risks. In this study, a novel pH/glutathione dual-responsive pesticide delivery system was constructed through the synthesis of disulfide-bridged hollow mesoporous organosilica nanospheres (HMONs) <i>via</i> the Stöber method, followed by poly(acrylic acid) (PAA) coating through distillation-precipitation polymerization to form HMONs@PAA nanocomposites. The resulting abamectin-loaded system (Abamectin-HMONs@PAA) demonstrated a 12.73% pesticide loading capacity and significantly improved photostability, retaining twice as much active ingredient as free abamectin after 250 h of UV irradiation (36 W). Release studies revealed pH- and glutathione-dependent characteristics, with cumulative releases in acidic conditions exceeding those in neutral and alkaline environments by 18.66% and 40.98%, respectively, and a 14.2% increase in glutathione-containing solution (0.2 mmol·L⁻¹ in 70% ethanol) after 97 h. Bioassays showed superior performance against <i>Plutella xylostella</i>, with a 13.33% reduction in survival rate compared to conventional suspension at equivalent dosage (40 mg·L⁻¹), while maintaining efficacy after extensive rainfall simulation (20 events over 10 days). This study provides a promising approach for developing environmentally responsive nanopesticides with enhanced durability and controlled-release properties, offering significant potential for sustainable crop protection.</p>