<p>The Middle East and North Africa (MENA) region is confronted with a complex set of challenges, including socio-economic disparities, healthcare system deficiencies, and escalating climate-related risks. This study aims to provide an analytical approach of the interconnections between socio-economic factors, healthcare infrastructure, and climate change to assess the climate resilience of countries in the MENA region. The specific objectives of the study are to identify and classify climate resilience indicators into four thematic categories, and develop corresponding sub-indices for each; assess and compare these indicators and sub-indices across MENA countries to capture key patterns, disparities, and statistical relationships; construct a composite climate resilience index for each country by integrating the four sub-indices; quantify the influence of each indicator to the variance of the composite index, thereby identifying the most influential drivers of climate resilience; identify country-specific priority areas for intervention based on resilience performance; and examine the relationship between NbS engagement in MENA countries and both the overall climate resilience index and its thematic sub-indices. The findings reveal significant differences in climate resilience levels across the MENA region. Socio-economic and healthcare dimensions emerge as the strongest statistical drivers of climate resilience. Furthermore, the analysis shows considerable variation in the adoption of NbS across countries, often shaped by national capacity, economic status, and institutional readiness. These results underscore the urgent need for integrated strategies that enhance socio-economic development, improve healthcare systems, strengthen adaptive capacity, and promote the use of nature-based solutions where feasible.</p>