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Purpose <p>This study aimed to investigate the biochemical and morphological effects of photobiomodulation (PBM) and supplementation with clarified açaí on the submandibular glands in a chemically induced oral mucositis model in rats. Methods: 102 rats were divided into five groups- control: no induction of oral mucositis (OM); untreated group: OM induction, no treatment; PBM: OM induction and laser application (660&#xa0;nm, 100 mW, 0.24&#xa0;J, 2.4&#xa0;s per point, 8&#xa0;J/cm<sup>2</sup> and in contact only at the OM site, bilaterally); açaí: OM induction and supplementation with clarified açaí; and PBM + açaí: OM induction and combination of the two treatments mentioned above. Oral mucositis was chemically induced by 5-fluorouracil (5-FU) on days 0 (60&#xa0;mg/kg) and 2 (40&#xa0;mg/kg). PMB and supplementation with clarified açaí (dose of 1&#xa0;ml/100&#xa0;g body weight) were used from day 0 of the experiment until euthanasia. On days 0 (control group), 8, 10, and 14 (intervention groups), submandibular glands were collected for analysis, with the right side used for oxidative biochemical analysis and the left side for histological analysis. A two-way statistical analysis of variance (ANOVA) was performed, followed by Tukey's post-hoc test (p &lt; 0.05). Results: PMB, alone or in combination with clarified açaí, significantly increased antioxidant capacity levels and showed significantly lower levels of lipid peroxidation and nitric oxide metabolites compared to the control group (p &lt; 0.0001). Morphologically, PBM, alone or combined with clarified açaí, maintained parenchyma, stroma, and acinar structures similar to the control group, which was not subjected to OM induction. Conclusion: It was experimentally demonstrated that PBM, when used alone or combined with clarified açaí, resulted in improved antioxidant response, in addition to providing glandular protection against structural damage caused by chemotherapy.</p>

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Preclinical evidence of photobiomodulation and clarified açaí in submandibular gland protection during antineoplastic therapy: an experimental study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月30日

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  • Wallacy Watson Pereira Melo,
  • Walessa Alana Bragança Aragão,
  • Leonardo de Oliveira Bittencourt,
  • Luciana Eiró-Quirino,
  • Paulo Fernando Santos Mendes,
  • Vinicius Ruan Neves Santos,
  • Hadassa Helez Neves Ferreira,
  • José Messias Perdigão,
  • Hannah Gil de Farias Morais,
  • Herve Rogez,
  • Roseana Almeida Freitas,
  • Manoela Domingues Martins,
  • Rafael Rodrigues Lima,
  • Renata Duarte de Souza-Rodrigues

摘要

Purpose

This study aimed to investigate the biochemical and morphological effects of photobiomodulation (PBM) and supplementation with clarified açaí on the submandibular glands in a chemically induced oral mucositis model in rats. Methods: 102 rats were divided into five groups- control: no induction of oral mucositis (OM); untreated group: OM induction, no treatment; PBM: OM induction and laser application (660 nm, 100 mW, 0.24 J, 2.4 s per point, 8 J/cm2 and in contact only at the OM site, bilaterally); açaí: OM induction and supplementation with clarified açaí; and PBM + açaí: OM induction and combination of the two treatments mentioned above. Oral mucositis was chemically induced by 5-fluorouracil (5-FU) on days 0 (60 mg/kg) and 2 (40 mg/kg). PMB and supplementation with clarified açaí (dose of 1 ml/100 g body weight) were used from day 0 of the experiment until euthanasia. On days 0 (control group), 8, 10, and 14 (intervention groups), submandibular glands were collected for analysis, with the right side used for oxidative biochemical analysis and the left side for histological analysis. A two-way statistical analysis of variance (ANOVA) was performed, followed by Tukey's post-hoc test (p < 0.05). Results: PMB, alone or in combination with clarified açaí, significantly increased antioxidant capacity levels and showed significantly lower levels of lipid peroxidation and nitric oxide metabolites compared to the control group (p < 0.0001). Morphologically, PBM, alone or combined with clarified açaí, maintained parenchyma, stroma, and acinar structures similar to the control group, which was not subjected to OM induction. Conclusion: It was experimentally demonstrated that PBM, when used alone or combined with clarified açaí, resulted in improved antioxidant response, in addition to providing glandular protection against structural damage caused by chemotherapy.