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<p>This study aimed to compare the effects of red- and blue-light intravascular laser irradiation of blood (ILIB) on stroke-related biomarkers and neurological recovery in post-stroke patients.&#xa0;In this double-blind, randomized, case-crossover trial, 30 patients within 6 months post-stroke received 10 sessions each of red-light and blue-light ILIB in randomized order with a two-month washout. Outcomes included blood count, biochemical markers (glucose, coagulation, inflammation), and neurological assessments (Fugl-Meyer Upper Limb, Berg Balance Scale, Mini-Mental State Examination). Paired t-tests and two-way ANOVA were applied.&#xa0;Red-light (650&#xa0;nm) ILIB reduced RBC count (− 0.08 × 10^6/µL; 95% CI − 0.16 to − 0.002) and fibrinogen (− 27.6&#xa0;mg/dL; 95% CI − 50.27 to − 4.93) versus baseline, and further decreased RBC (− 0.13 × 10^6/µL; 95% CI − 0.26 to − 0.02) and hematocrit (− 1.12%; 95% CI − 2.48 to − 0.14) compared with blue-light (415&#xa0;nm) ILIB. Age-stratified analysis showed that in older adults, red-light ILIB reduced erythrocyte indices (RBC − 0.14 × 10⁶/µL, Hb − 0.43&#xa0;g/dL, Hct − 1.31%), while in younger participants, red-light ILIB lowered inflammatory markers (IL-6 − 1.91 pg/mL, fibrinogen − 29.6&#xa0;mg/dL). For neurological function, both red-light and blue-light ILIB improved motor and balance performance without significant between-group differences. In age-stratified analysis, blue-light ILIB improved motor function in both age groups (FMA-UE: old + 2.80, young + 4.27) and enhanced balance (BBS: old + 4.33, young + 4.47), whereas red-light ILIB further improved upper-limb function in older adults (FMA-UE + 2.13) and cognition in younger participants (MMSE + 1.93).&#xa0;ILIB at different wavelengths may differentially influence hematologic and inflammatory biomarkers associated with stroke risk and functional recovery. These findings warrant further investigation in larger and longer-term studies.</p>

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The effects of intravenous laser irradiation of blood with red and blue light on stroke risk biomarkers and neurological function: a double blind randomized controlled trial

  • 期刊论文

  • 发表日期：

    2025年12月22日

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  • Huan-Jui Yeh,
  • Hui-Chen Cheng,
  • Austin Shih,
  • Felipe Fregni

摘要

This study aimed to compare the effects of red- and blue-light intravascular laser irradiation of blood (ILIB) on stroke-related biomarkers and neurological recovery in post-stroke patients. In this double-blind, randomized, case-crossover trial, 30 patients within 6 months post-stroke received 10 sessions each of red-light and blue-light ILIB in randomized order with a two-month washout. Outcomes included blood count, biochemical markers (glucose, coagulation, inflammation), and neurological assessments (Fugl-Meyer Upper Limb, Berg Balance Scale, Mini-Mental State Examination). Paired t-tests and two-way ANOVA were applied. Red-light (650 nm) ILIB reduced RBC count (− 0.08 × 10^6/µL; 95% CI − 0.16 to − 0.002) and fibrinogen (− 27.6 mg/dL; 95% CI − 50.27 to − 4.93) versus baseline, and further decreased RBC (− 0.13 × 10^6/µL; 95% CI − 0.26 to − 0.02) and hematocrit (− 1.12%; 95% CI − 2.48 to − 0.14) compared with blue-light (415 nm) ILIB. Age-stratified analysis showed that in older adults, red-light ILIB reduced erythrocyte indices (RBC − 0.14 × 10⁶/µL, Hb − 0.43 g/dL, Hct − 1.31%), while in younger participants, red-light ILIB lowered inflammatory markers (IL-6 − 1.91 pg/mL, fibrinogen − 29.6 mg/dL). For neurological function, both red-light and blue-light ILIB improved motor and balance performance without significant between-group differences. In age-stratified analysis, blue-light ILIB improved motor function in both age groups (FMA-UE: old + 2.80, young + 4.27) and enhanced balance (BBS: old + 4.33, young + 4.47), whereas red-light ILIB further improved upper-limb function in older adults (FMA-UE + 2.13) and cognition in younger participants (MMSE + 1.93). ILIB at different wavelengths may differentially influence hematologic and inflammatory biomarkers associated with stroke risk and functional recovery. These findings warrant further investigation in larger and longer-term studies.