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<p>To evaluate whether Er: YAG surgery and Nd: YAG-based low-level laser therapy (LLLT), combined with medical collagen, improve early postoperative outcomes after extraction of impacted mandibular third molars.&#xa0;Adults undergoing surgical removal of mesioangular or horizontal impacted mandibular third molars were randomized equally (1:1:1:1) to blank control (BCG), collagen only (COL), lasers only (LAS), or collagen plus lasers (COL + LAS). <b>Primary endpoints</b> were pain (VAS; spontaneous and swallowing; POD1/3/7), swelling (POD1/3/7), trismus (POD1/3/7), and early mucosal healing (POD3/7). <b>Secondary endpoints</b> were bleeding (30&#xa0;min post-extraction only), cutaneous induration/ecchymosis (POD7), alveolar osteitis (POD3/7), and local cytokines (IL-1β, IL-6, TNF-α; POD3/7).&#xa0;In 120 patients, <b>COL + LAS</b> was superior: less pain, swelling, and trismus at <b>POD1/3</b> and higher early mucosal-healing rates at <b>POD3/7</b> than <b>BCG</b>, <b>COL</b>, or <b>LAS</b>; by <b>POD7</b>, between-group differences in pain, swelling, and trismus were minimal. All active arms reduced <b>30-min bleeding</b> versus BCG. At <b>POD7</b>, cutaneous induration was lowest with COL + LAS (ecchymosis not significant). Cytokines declined overall; <b>IL-1β</b> and <b>TNF-α</b> were lowest with COL + LAS at <b>POD3/7</b>, whereas <b>IL-6</b> decreased similarly across active arms.&#xa0;Er: YAG surgery plus Nd: YAG-based LLLT with medical collagen improved short-term recovery after impacted mandibular third-molar surgery.</p>

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Er:YAG and Nd:YAG-based low-level laser therapy (LLLT) with medical collagen improve third-molar extraction wound healing: a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月8日

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  • Zhantang Yuan,
  • Zhihui Xu,
  • Xia Wan,
  • Tonghan Zhang

摘要

To evaluate whether Er: YAG surgery and Nd: YAG-based low-level laser therapy (LLLT), combined with medical collagen, improve early postoperative outcomes after extraction of impacted mandibular third molars. Adults undergoing surgical removal of mesioangular or horizontal impacted mandibular third molars were randomized equally (1:1:1:1) to blank control (BCG), collagen only (COL), lasers only (LAS), or collagen plus lasers (COL + LAS). Primary endpoints were pain (VAS; spontaneous and swallowing; POD1/3/7), swelling (POD1/3/7), trismus (POD1/3/7), and early mucosal healing (POD3/7). Secondary endpoints were bleeding (30 min post-extraction only), cutaneous induration/ecchymosis (POD7), alveolar osteitis (POD3/7), and local cytokines (IL-1β, IL-6, TNF-α; POD3/7). In 120 patients, COL + LAS was superior: less pain, swelling, and trismus at POD1/3 and higher early mucosal-healing rates at POD3/7 than BCG, COL, or LAS; by POD7, between-group differences in pain, swelling, and trismus were minimal. All active arms reduced 30-min bleeding versus BCG. At POD7, cutaneous induration was lowest with COL + LAS (ecchymosis not significant). Cytokines declined overall; IL-1β and TNF-α were lowest with COL + LAS at POD3/7, whereas IL-6 decreased similarly across active arms. Er: YAG surgery plus Nd: YAG-based LLLT with medical collagen improved short-term recovery after impacted mandibular third-molar surgery.