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<p>Dental mesenchymal stem cells (DMSCs) are increasingly recognized for their regenerative properties, particularly in the context of pulp regeneration. Among the various treatment’s diode laser irradiation, has gained more attention for its potential to promote stem cell differentiation, particularly osteogenic differentiation.&#xa0;To evaluate the effect of diode laser irradiation on the proliferation and osteogenic differentiation of dental tissue-derived mesenchymal stem cells.&#xa0;A comprehensive search was performed between January 2025 to June 2025 across five databases including PubMed, Cochrane Library, LILACA, Google scholar and ScienceDirect. Only in vitro studies that assessed cellular or osteogenic differentiation of DMSCS were included. The risk of bias for was assessed using the QUIN tool.&#xa0;A total of 21 studies were included in the review, encompassing various DMSC types, The studies explored a range of diode laser wavelengths (420–980&#xa0;nm) and energy densities. Findings indicate that diode laser irradiation, particularly at wavelengths of 660&#xa0;nm, 810&#xa0;nm, and 980&#xa0;nm, promotes osteogenic differentiation by enhancing the expression of osteogenic markers such as RUNX2, ALP, and OCN. The effect of diode laser irradiation on stem cell proliferation and osteogenic differentiation was found to be dose-dependent, with lower energy densities promoting proliferation and higher energy densities favoring differentiation.&#xa0;Diode laser irradiation at wavelengths of 660&#xa0;nm, 810&#xa0;nm, and 980&#xa0;nm demonstrates potential for enhancing osteogenic differentiation of DMSCs. However, variability in laser parameters led to inconsistencies in the results, and no consensus could be reached regarding the optimal laser settings for maximum differentiation efficiency.</p>

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Effect of diode laser irradiation on stemness of dental Tissues - A systematic review

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Dr Shubham Lawate,
  • Dr Anita Kulloli,
  • Dr Sharath Shetty,
  • Dr Santosh Martande,
  • Dr Ketan Deshetti,
  • Dr Sheetal Zargad,
  • Dr Shishir Zargad

摘要

Dental mesenchymal stem cells (DMSCs) are increasingly recognized for their regenerative properties, particularly in the context of pulp regeneration. Among the various treatment’s diode laser irradiation, has gained more attention for its potential to promote stem cell differentiation, particularly osteogenic differentiation. To evaluate the effect of diode laser irradiation on the proliferation and osteogenic differentiation of dental tissue-derived mesenchymal stem cells. A comprehensive search was performed between January 2025 to June 2025 across five databases including PubMed, Cochrane Library, LILACA, Google scholar and ScienceDirect. Only in vitro studies that assessed cellular or osteogenic differentiation of DMSCS were included. The risk of bias for was assessed using the QUIN tool. A total of 21 studies were included in the review, encompassing various DMSC types, The studies explored a range of diode laser wavelengths (420–980 nm) and energy densities. Findings indicate that diode laser irradiation, particularly at wavelengths of 660 nm, 810 nm, and 980 nm, promotes osteogenic differentiation by enhancing the expression of osteogenic markers such as RUNX2, ALP, and OCN. The effect of diode laser irradiation on stem cell proliferation and osteogenic differentiation was found to be dose-dependent, with lower energy densities promoting proliferation and higher energy densities favoring differentiation. Diode laser irradiation at wavelengths of 660 nm, 810 nm, and 980 nm demonstrates potential for enhancing osteogenic differentiation of DMSCs. However, variability in laser parameters led to inconsistencies in the results, and no consensus could be reached regarding the optimal laser settings for maximum differentiation efficiency.