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<p>Skin aging is characterized by the degradation of dermal collagen, leading to wrinkles, loss of elasticity, and structural deterioration. Non-ablative laser treatments have been widely used to stimulate collagen production by selectively inducing thermal effects in the dermis without causing damage to the epidermis. Various wavelengths have been employed to effectively target different depths of the dermal layer. The current research aims to investigate the therapeutic potential of a triple-wavelength laser system (755, 808, and 1064&#xa0;nm) in enhancing collagen synthesis throughout the dermis for skin rejuvenation. Ex vivo porcine skin was used to evaluate the penetration depth and extent of thermal damage at each wavelength. In vivo tests were performed using guinea pigs to measure changes in epidermal thickness and collagen density. Histological analysis showed that the depth of thermal damage increased with longer wavelengths, and the triple-wavelength indicated a penetration depth comparable to that of the 1064&#xa0;nm wavelength. Furthermore, the triple-wavelength resulted in a significant increase in epidermal thickness and collagen density in the dermal layer compared to the 1064&#xa0;nm wavelength. The current study demonstrated the feasibility of the application of simultaneous triple-wavelength irradiation for skin rejuvenation. Further studies will be conducted to investigate the performance of the current findings in in vivo large animal models under various parameters, such as number of shots and treatments, treatment frequency, and various fluence levels.</p>

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Investigation of therapeutic potential of simultaneous triple-wavelength laser technology for skin rejuvenation

  • 期刊论文

  • 发表日期：

    2025年8月21日

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  • Jiho Lee,
  • Hwarang Shin,
  • Minh Duc Ta,
  • Jongman Choi,
  • Hyun Wook Kang

摘要

Skin aging is characterized by the degradation of dermal collagen, leading to wrinkles, loss of elasticity, and structural deterioration. Non-ablative laser treatments have been widely used to stimulate collagen production by selectively inducing thermal effects in the dermis without causing damage to the epidermis. Various wavelengths have been employed to effectively target different depths of the dermal layer. The current research aims to investigate the therapeutic potential of a triple-wavelength laser system (755, 808, and 1064 nm) in enhancing collagen synthesis throughout the dermis for skin rejuvenation. Ex vivo porcine skin was used to evaluate the penetration depth and extent of thermal damage at each wavelength. In vivo tests were performed using guinea pigs to measure changes in epidermal thickness and collagen density. Histological analysis showed that the depth of thermal damage increased with longer wavelengths, and the triple-wavelength indicated a penetration depth comparable to that of the 1064 nm wavelength. Furthermore, the triple-wavelength resulted in a significant increase in epidermal thickness and collagen density in the dermal layer compared to the 1064 nm wavelength. The current study demonstrated the feasibility of the application of simultaneous triple-wavelength irradiation for skin rejuvenation. Further studies will be conducted to investigate the performance of the current findings in in vivo large animal models under various parameters, such as number of shots and treatments, treatment frequency, and various fluence levels.