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Introduction <p>diseases caused by antibiotic-resistant bacteria pose a growing global health challenge. Photodynamic Therapy (PDT), which uses light-activated photosensitizers to kill bacteria, offers a promising alternative. This study evaluates the antibacterial efficacy of gold nanoparticles synthesized from mangosteen peel extract (AuNPs-GML) combined with blue diode laser irradiation against <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>), two common pathogens.</p> Materials and methods <p>Four treatments were applied: control (no treatment), AuNPs-GML alone, blue laser irradiation alone (405&#xa0;nm), and a combination of AuNPs-GML with laser irradiation. Samples were incubated at 37&#xa0;°C for 24&#xa0;h before bacterial viability was assessed. Statistical analysis was performed using Two-Way ANOVA and Tukey’s post hoc test (p &lt; 0.05).</p> Results <p>Results showed that combining AuNPs-GML with blue laser irradiation significantly enhanced bacterial inactivation compared to laser or nanoparticles alone. At 180 seconds irradiation and 2 mM AuNPs-GML concentration, bacterial reduction reached 86.25% for <i>E. coli</i> and 72.84% for <i>S. aureus</i> at an energy density of 3.34 J/cm2.</p> Conclusion <p>This study demonstrates the potential of AuNPs-GML activated by blue laser PDT as an effective antibacterial treatment against resistant bacteria.</p>

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Photodynamic antibacterial activity of green-synthesized gold nanoparticles from mangosteen peel extract using blue laser irradiation

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • Deny Arifianto,
  • Suryani Dyah Astuti,
  • Baby Mutiara Lusiani,
  • Andi Hamim Zaidan,
  • Winarno Winarno,
  • Ahmad Khalil Yaqubi,
  • Yunus Susilo,
  • Karwan Wasman Qadir,
  • Ardiansyah Syahrom

摘要

Introduction

diseases caused by antibiotic-resistant bacteria pose a growing global health challenge. Photodynamic Therapy (PDT), which uses light-activated photosensitizers to kill bacteria, offers a promising alternative. This study evaluates the antibacterial efficacy of gold nanoparticles synthesized from mangosteen peel extract (AuNPs-GML) combined with blue diode laser irradiation against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), two common pathogens.

Materials and methods

Four treatments were applied: control (no treatment), AuNPs-GML alone, blue laser irradiation alone (405 nm), and a combination of AuNPs-GML with laser irradiation. Samples were incubated at 37 °C for 24 h before bacterial viability was assessed. Statistical analysis was performed using Two-Way ANOVA and Tukey’s post hoc test (p < 0.05).

Results

Results showed that combining AuNPs-GML with blue laser irradiation significantly enhanced bacterial inactivation compared to laser or nanoparticles alone. At 180 seconds irradiation and 2 mM AuNPs-GML concentration, bacterial reduction reached 86.25% for E. coli and 72.84% for S. aureus at an energy density of 3.34 J/cm2.

Conclusion

This study demonstrates the potential of AuNPs-GML activated by blue laser PDT as an effective antibacterial treatment against resistant bacteria.