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<p>The increasing resistance of <i>Pseudomonas aeruginosa</i> to carbapenem antibiotics is shifting the landscape of high-risk clones from a strictly hospital-acquired threat to a global pathogen with One Health relevance. Given the limited therapeutic options available, developing new treatments is essential. We previously reported the complete genome sequence of φSPM-1 phage from the family <i>Myoviridae</i>. In this study, we show that φSPM-1 displays lytic activity against hospital and environmental metallo-β-lactamase (MβL)-producing <i>P. aeruginosa</i> and confers a protective effect against lethal infection caused by the high-risk clone ST277 in a <i>Galleria mellonella</i> prophylactic model.</p>

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Lytic activity of F8-like phage φSPM-1 against One Health lineages of carbapenem-resistant Pseudomonas aeruginosa

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Patrícia R. Neves,
  • Karine Dantas,
  • Gregory Melocco,
  • Helena Turano,
  • Fernanda Esposito,
  • Ana C. Gales,
  • Carlo E. Levy,
  • Elsa M. Mamizuka,
  • Nilton Lincopan

摘要

The increasing resistance of Pseudomonas aeruginosa to carbapenem antibiotics is shifting the landscape of high-risk clones from a strictly hospital-acquired threat to a global pathogen with One Health relevance. Given the limited therapeutic options available, developing new treatments is essential. We previously reported the complete genome sequence of φSPM-1 phage from the family Myoviridae. In this study, we show that φSPM-1 displays lytic activity against hospital and environmental metallo-β-lactamase (MβL)-producing P. aeruginosa and confers a protective effect against lethal infection caused by the high-risk clone ST277 in a Galleria mellonella prophylactic model.