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<p>We report the case of catheter-related bloodstream infection (CRBSI) potentially associated with probiotic administration of <i>Bacillus subtilis</i> subsp. <i>subtilis</i>. A 32⁺⁵-week preterm infant developed systemic inflammation during oral probiotic therapy. CRBSI was definitively diagnosed via differential time to positivity between peripheral and catheter-drawn blood cultures. Microbiological analysis demonstrated that clinical isolates and the probiotic strain shared identical antimicrobial susceptibility profiles; however, this is not definitive proof of strain identity. This novel case suggests a potential infectious risk for <i>B. subtilis</i> in neonates with central venous access and underscores the necessity of considering probiotics as a potential source of catheter-related sepsis.</p>

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Probiotic-associated Bacillus subtilis subsp. subtilis catheter-related bloodstream infection in a preterm infant: a caution for neonatal intensive care units

  • 期刊论文

  • 发表日期：

    2026年6月25日

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  • Jiajia Chen,
  • Xuelan Liu,
  • Xiang Huang,
  • Manzhi Huang

摘要

We report the case of catheter-related bloodstream infection (CRBSI) potentially associated with probiotic administration of Bacillus subtilis subsp. subtilis. A 32⁺⁵-week preterm infant developed systemic inflammation during oral probiotic therapy. CRBSI was definitively diagnosed via differential time to positivity between peripheral and catheter-drawn blood cultures. Microbiological analysis demonstrated that clinical isolates and the probiotic strain shared identical antimicrobial susceptibility profiles; however, this is not definitive proof of strain identity. This novel case suggests a potential infectious risk for B. subtilis in neonates with central venous access and underscores the necessity of considering probiotics as a potential source of catheter-related sepsis.