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<p>Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in hematologic malignancy patients and hematopoietic cell transplant (HCT) recipients. Mold cholecystitis has rarely been described. We present a case of disseminated <i>Lomentospora prolificans</i>, that had recrudescence of symptoms with acute cholecystitis. Treatment included a temporary cholecystostomy and administration of the novel antifungal fosmanogepix. At 6 weeks post-HCT, the patient underwent cholecystectomy and completed a course of fosmanogepix, leading to resolution of her infection. Here we review the published literature on non-<i>Candida</i> fungal cholecystitis, underlying risk factors and treatment.</p>

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Non-Candida fungal cholecystitis - an uncommon occurrence even in the right host

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月14日

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  • Mitchell G. Dumais,
  • Mary M. Czech,
  • Mustafa A. Hyder,
  • Rachel R. Lee,
  • Juan C. Gea-Banacloche,
  • Christopher G. Kanakry,
  • Sun A. Kim,
  • Bindu Adhikari,
  • Matthew D. Surette,
  • Adrian M. Zelazny,
  • Amir Seyedmousavi,
  • Jennifer M. Cuellar-Rodriguez

摘要

Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in hematologic malignancy patients and hematopoietic cell transplant (HCT) recipients. Mold cholecystitis has rarely been described. We present a case of disseminated Lomentospora prolificans, that had recrudescence of symptoms with acute cholecystitis. Treatment included a temporary cholecystostomy and administration of the novel antifungal fosmanogepix. At 6 weeks post-HCT, the patient underwent cholecystectomy and completed a course of fosmanogepix, leading to resolution of her infection. Here we review the published literature on non-Candida fungal cholecystitis, underlying risk factors and treatment.