Scholarlink

<p>This study evaluates the in vitro activity of five clinically-relevant β-lactam antibiotics against 158 <i>Enterococcus faecalis</i> clinical isolates from France and assesses whether ampicillin (AMP) disc diffusion can predict susceptibility. No β-lactamase-producing strains were detected and 100% of them remained susceptible to amoxicillin. By contrast, resistance was detected for piperacillin, imipenem, meropenem and ceftobiprole (8.9, 2.5, 24.4 and 13.9%, respectively). Whereas AMP disc testing can reliably predict susceptibility to amoxicillin, it showed very poor performances for other several β-lactams. Overall, aminopenicillins remain the first-line treatment, but MIC determination is recommended for accurate assessment of resistance to other β-lactams.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

In vitro activity of β-lactams against contemporary Enterococcus faecalis clinical isolates and performances of disc diffusion testing for prediction of β-lactam susceptibility

  • 期刊论文

  • 发表日期：

    2026年4月14日

查看全文
  • Asma Zouari,
  • Sophie Reissier,
  • Marlène Amara,
  • Maxime Lecourt,
  • Flavie Marie,
  • Gabriel Auger,
  • Vincent Cattoir,
  • François Guérin

摘要

This study evaluates the in vitro activity of five clinically-relevant β-lactam antibiotics against 158 Enterococcus faecalis clinical isolates from France and assesses whether ampicillin (AMP) disc diffusion can predict susceptibility. No β-lactamase-producing strains were detected and 100% of them remained susceptible to amoxicillin. By contrast, resistance was detected for piperacillin, imipenem, meropenem and ceftobiprole (8.9, 2.5, 24.4 and 13.9%, respectively). Whereas AMP disc testing can reliably predict susceptibility to amoxicillin, it showed very poor performances for other several β-lactams. Overall, aminopenicillins remain the first-line treatment, but MIC determination is recommended for accurate assessment of resistance to other β-lactams.