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<p>Here we characterized the genome on a <i>K. pneumoniae</i> strain carrying the <i>bla</i><sub>KPC-184</sub> variant and the integrated prophage regions. Genomic analysis showed that the KP-OL-VR-24 strain belonged to the ST307 and carried a variant of <i>bla</i><sub>KPC-3</sub>, named <i>bla</i><sub>KPC-184</sub><i>.</i> Sequence alignment showed that KPC-184 differed by KPC-3 by E274D substitution. Of note, <i>bla</i><sub>KPC-184</sub> gene was embedded in a prophage region showing a high homology with p45-lncX3 plasmid. Our findings highlighted the role of prophages in the dissemination of the <i>bla</i><sub>KPC</sub> gene, thus emphasizing the need for molecular surveillance to control the diffusion of public health threats.</p>

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Characterization of prophage carrying blaKPC-184 in a ST307 Klebsiella pneumoniae clinical isolate from Italy

  • 期刊论文

  • 发表日期：

    2026年2月9日

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  • Patricia Marie-Jeanne Lievens,
  • Roberta Galavotti,
  • Luca Caiazzo,
  • Laura Macacaro,
  • Caterina Signoretto,
  • Paolo Gaibani

摘要

Here we characterized the genome on a K. pneumoniae strain carrying the blaKPC-184 variant and the integrated prophage regions. Genomic analysis showed that the KP-OL-VR-24 strain belonged to the ST307 and carried a variant of blaKPC-3, named blaKPC-184. Sequence alignment showed that KPC-184 differed by KPC-3 by E274D substitution. Of note, blaKPC-184 gene was embedded in a prophage region showing a high homology with p45-lncX3 plasmid. Our findings highlighted the role of prophages in the dissemination of the blaKPC gene, thus emphasizing the need for molecular surveillance to control the diffusion of public health threats.