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Background <p>Hepatitis C virus (HCV) infection remains a global health challenge despite the availability of highly effective direct-acting antivirals. Early case identification through population screening is crucial to achieve the WHO target of HCV elimination. We conducted a population-based screening program in the Marche Region (Italy), focusing on the Local Health Authority of Pesaro–Urbino, to evaluate the feasibility and first-year outcomes of the national HCV screening campaign.</p> Methods <p>Between August 2023 and July 2024, individuals born between 1969 and 1989 residing in the Pesaro–Urbino area were invited to undergo free HCV testing. Screening was performed using serological anti-HCV antibody assays, and positive cases were further evaluated with HCV-RNA testing to confirm active infection.</p> Results <p>A total of 6,319 individuals (12.4% of the eligible population) participated in the screening program. Anti-HCV antibodies were detected in 64 participants (1.0%). Among them, 8 cases (0.13% of the total screened) showed detectable HCV-RNA, confirming ongoing infection.</p> Conclusions <p>The prevalence of active HCV infection in this population was low, consistent with declining national and European trends. However, the program successfully identified untreated viremic individuals who can now access curative therapy. Our findings highlight both the importance and the challenges of implementing large-scale screening campaigns in low-prevalence settings, emphasizing the need for tailored strategies to maximize participation rates and achieve elimination goals.</p>

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Evaluation of the hepatitis c virus screening program in the Marche Region (Italy): experience from the Pesaro–Urbino health authority

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月11日

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  • Raffaele La Porta,
  • Antonio Vitiello,
  • Annalisa Belli,
  • Davide Sisti,
  • Andrea Zovi,
  • Francesca Bruscolini,
  • Saverio Guerra,
  • Sara Carbonari,
  • Sara Di Benedetto,
  • Tania Rodini,
  • Simone Barocci,
  • Stefano Amatori

摘要

Background

Hepatitis C virus (HCV) infection remains a global health challenge despite the availability of highly effective direct-acting antivirals. Early case identification through population screening is crucial to achieve the WHO target of HCV elimination. We conducted a population-based screening program in the Marche Region (Italy), focusing on the Local Health Authority of Pesaro–Urbino, to evaluate the feasibility and first-year outcomes of the national HCV screening campaign.

Methods

Between August 2023 and July 2024, individuals born between 1969 and 1989 residing in the Pesaro–Urbino area were invited to undergo free HCV testing. Screening was performed using serological anti-HCV antibody assays, and positive cases were further evaluated with HCV-RNA testing to confirm active infection.

Results

A total of 6,319 individuals (12.4% of the eligible population) participated in the screening program. Anti-HCV antibodies were detected in 64 participants (1.0%). Among them, 8 cases (0.13% of the total screened) showed detectable HCV-RNA, confirming ongoing infection.

Conclusions

The prevalence of active HCV infection in this population was low, consistent with declining national and European trends. However, the program successfully identified untreated viremic individuals who can now access curative therapy. Our findings highlight both the importance and the challenges of implementing large-scale screening campaigns in low-prevalence settings, emphasizing the need for tailored strategies to maximize participation rates and achieve elimination goals.