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Objective <p>To investigate the pathogens and clinical characteristics of necrotizing pneumonia (NP) in our hospital from January 2019 to June 2025.</p> Methods <p>We retrospectively analyzed the clinical data of children with NP. Patients were divided into a single- bronchoalveolar lavage (BAL) group and a multiple-BAL group. Pathogens and clinical characteristics were compared between the two groups.</p> Results <p>This study included 365 patients with NP, 193 of whom were males. The incidence of NP significantly increased in 2023—2024. The pathogen identification rate was 98.36%, with <i>Mycoplasma pneumoniae</i> (MP) being the most commonly pathogen (91.00%). There were 138 cases of mixed infection and 227 cases of single infection. The 335 cases underwent BAL, with 139 cases assigned to the single-BAL group. Follow-up within 6 months after discharge was conducted for 238 patients, and the majority exhibited a favorable prognosis. No statistical differences were observed between the two groups regarding gender, age, time from onset to diagnosis, or duration of fever. However, a significant difference was noted in the length of hospital stay (<i>P</i> &lt; 0.05). The infection rate of MP in the single-BAL group was lower than that in the multiple-BAL group (<i>P</i> &lt; 0.05).</p> Conclusion <p>The incidence of NP significantly increased in 2023–2024, with MP as the predominant pathogen. Children with NP present with severe clinical symptoms, a prolonged disease course, and significantly elevated inflammatory markers. Most NP patients have a favorable prognosis. Patients requiring multiple BAL procedures demonstrate a higher MP infection rate.</p>

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Analysis of the pathogens and clinical characteristics of pediatric necrotizing pneumonia patients in a tertiary grade a hospital from 2019 to 2025: a retrospective study design

  • 期刊论文

  • 发表日期：

    2025年11月15日

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  • Zewen Ding,
  • Jiapu Hou,
  • Ruiyang Sun,
  • Wanyu Jia,
  • Peng Li,
  • Chunlan Song

摘要

Objective

To investigate the pathogens and clinical characteristics of necrotizing pneumonia (NP) in our hospital from January 2019 to June 2025.

Methods

We retrospectively analyzed the clinical data of children with NP. Patients were divided into a single- bronchoalveolar lavage (BAL) group and a multiple-BAL group. Pathogens and clinical characteristics were compared between the two groups.

Results

This study included 365 patients with NP, 193 of whom were males. The incidence of NP significantly increased in 2023—2024. The pathogen identification rate was 98.36%, with Mycoplasma pneumoniae (MP) being the most commonly pathogen (91.00%). There were 138 cases of mixed infection and 227 cases of single infection. The 335 cases underwent BAL, with 139 cases assigned to the single-BAL group. Follow-up within 6 months after discharge was conducted for 238 patients, and the majority exhibited a favorable prognosis. No statistical differences were observed between the two groups regarding gender, age, time from onset to diagnosis, or duration of fever. However, a significant difference was noted in the length of hospital stay (P < 0.05). The infection rate of MP in the single-BAL group was lower than that in the multiple-BAL group (P < 0.05).

Conclusion

The incidence of NP significantly increased in 2023–2024, with MP as the predominant pathogen. Children with NP present with severe clinical symptoms, a prolonged disease course, and significantly elevated inflammatory markers. Most NP patients have a favorable prognosis. Patients requiring multiple BAL procedures demonstrate a higher MP infection rate.