Scholarlink

Objective <p>To analyze clinical features and identify prognostic factors in HIV/AIDS patients with cryptococcal meningitis (CM), and to develop a predictive model for short-term mortality.</p> Methods <p>A multicenter retrospective study was conducted on 197 HIV/AIDS patients diagnosed with CM from 2013 to 2023. Clinical data were collected, and multivariate logistic regression was used to construct a prognostic model.</p> Results <p>The median age was 48 years (IQR: 33–57.5), with 75.6% males. Common symptoms included headache (68.5%), fever (52.8%), and nausea/vomiting (49.2%). Independent risk factors for mortality were consciousness disturbance (OR = 7.785, <i>P</i> = 0.013) and elevated intracranial pressure (OR = 1.011, <i>P</i> = 0.023), while CD8<sup>+</sup>T lymphocytes (OR = 0.997, <i>P</i> = 0.022) and platelet count (OR = 0.990, <i>P</i> = 0.014) were protective. The prognostic model (AUC = 0.860, 95% CI: 0.776–0.943) demonstrated sensitivity of 71.4% and specificity of 89.3%.</p> Conclusion <p>Consciousness disturbance, intracranial pressure, CD8<sup>+</sup> T cells, and platelets independently predict mortality in HIV/AIDS-associated CM. Early intervention targeting these factors may improve outcomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Analysis of clinical characteristics and prognostic factors in AIDS complicated by cryptococcal meningitis

  • 期刊论文

  • 发表日期：

    2025年10月17日

查看全文
  • Yanlan Liang,
  • Xiyang Dong,
  • Yong Deng,
  • Zhende Lin,
  • Caixia Zheng,
  • Jiaxuan Li,
  • Yijie Lin,
  • Huatang Zhang,
  • Xing Wang,
  • Wenwu Lin,
  • Wencong Hong,
  • Su Zhang,
  • Zhijun Su,
  • Weidong Zhao,
  • Xiulan Xue,
  • Xue-Ping Yu

摘要

Objective

To analyze clinical features and identify prognostic factors in HIV/AIDS patients with cryptococcal meningitis (CM), and to develop a predictive model for short-term mortality.

Methods

A multicenter retrospective study was conducted on 197 HIV/AIDS patients diagnosed with CM from 2013 to 2023. Clinical data were collected, and multivariate logistic regression was used to construct a prognostic model.

Results

The median age was 48 years (IQR: 33–57.5), with 75.6% males. Common symptoms included headache (68.5%), fever (52.8%), and nausea/vomiting (49.2%). Independent risk factors for mortality were consciousness disturbance (OR = 7.785, P = 0.013) and elevated intracranial pressure (OR = 1.011, P = 0.023), while CD8+T lymphocytes (OR = 0.997, P = 0.022) and platelet count (OR = 0.990, P = 0.014) were protective. The prognostic model (AUC = 0.860, 95% CI: 0.776–0.943) demonstrated sensitivity of 71.4% and specificity of 89.3%.

Conclusion

Consciousness disturbance, intracranial pressure, CD8+ T cells, and platelets independently predict mortality in HIV/AIDS-associated CM. Early intervention targeting these factors may improve outcomes.