Scholarlink

<p><i>Streptococcus suis</i> (<i>S. suis</i>) is an important zoonotic pathogen that frequently causes meningitis, sepsis, infective endocarditis, and septic arthritis in humans. The objective of this study was to determine the epidemiological characteristics of <i>S. suis</i> infections in Nakhon Ratchasima Province, northeastern Thailand, between 2021 and 2023. A total of 448 cases of <i>S. suis</i> infection were reported in Nakhon Ratchasima Province, with cumulative incidences of 6.95, 5.09, and 5.15 per 100,000 population in 2021, 2022, and 2023, respectively. <i>S. suis</i> cases were occurred in all year. Infection caused by <i>S. suis</i> clonal complexes 1, 25, 104, 233, and the novel lineage ST1688 (serotype 2) which was significantly associated with infective endocarditis (IE) (OR = 2.96, 95% CI = 1.13–7.72; <i>p</i>-value = 0.027). Multivariate analysis demonstrated a significant risk of mortality associated with acute respiratory failure (OR 4.16, 95% CI = 2.15–8.08; <i>p</i>-value &lt; 0.001) and IE (OR 2.05, 95% CI = 1.06–3.98; <i>p</i>-value = 0.033). Conversely, IE followed by valve surgery (OR 0.02, 95% CI = 0.00-0.08; <i>p</i>-value &lt; 0.001) seemed to be a protective factor for patients with IE. This study revealed a high incidence of <i>S. suis</i> cases, in Nakhon Ratchasima, with a novel <i>S. suis</i> lineage associated with IE. Active surveillance and close monitoring of IE caused by <i>S. suis</i> should be prioritised.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Novel zoonotic Streptococcus suis lineage causes infective endocarditis with high mortality in Thailand

  • 期刊论文

  • 发表日期：

    2025年8月13日

查看全文
  • Rattagan Kajeekul,
  • Jaime Brizuela,
  • Narisa Ruenroengbun,
  • Constance Schultsz,
  • Anusak Kerdsin

摘要

Streptococcus suis (S. suis) is an important zoonotic pathogen that frequently causes meningitis, sepsis, infective endocarditis, and septic arthritis in humans. The objective of this study was to determine the epidemiological characteristics of S. suis infections in Nakhon Ratchasima Province, northeastern Thailand, between 2021 and 2023. A total of 448 cases of S. suis infection were reported in Nakhon Ratchasima Province, with cumulative incidences of 6.95, 5.09, and 5.15 per 100,000 population in 2021, 2022, and 2023, respectively. S. suis cases were occurred in all year. Infection caused by S. suis clonal complexes 1, 25, 104, 233, and the novel lineage ST1688 (serotype 2) which was significantly associated with infective endocarditis (IE) (OR = 2.96, 95% CI = 1.13–7.72; p-value = 0.027). Multivariate analysis demonstrated a significant risk of mortality associated with acute respiratory failure (OR 4.16, 95% CI = 2.15–8.08; p-value < 0.001) and IE (OR 2.05, 95% CI = 1.06–3.98; p-value = 0.033). Conversely, IE followed by valve surgery (OR 0.02, 95% CI = 0.00-0.08; p-value < 0.001) seemed to be a protective factor for patients with IE. This study revealed a high incidence of S. suis cases, in Nakhon Ratchasima, with a novel S. suis lineage associated with IE. Active surveillance and close monitoring of IE caused by S. suis should be prioritised.