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<p>This study focused on genomic epidemiology of metallo-β-lactamase (MBL)-producing <i>Citrobacter</i> spp. in Poland. It included 118 isolates with VIM (<i>n</i> = 100), NDM (<i>n</i> = 17) or IMP (<i>n</i> = 1) enzymes from 2011 to 19, largely <i>C. freundii</i> (<i>n</i> = 94) of 33 sequence types (STs). Three globally-spread STs were more prevalent, namely ST18 (<i>n</i> = 15), ST8 (<i>n</i> = 11) and ST22 (<i>n</i> = 10), each diversified clonally and by VIM and NDM determinants. Only few outbreaks were evidenced, indicating MBL presence to result mainly from independent acquisitions, consistent with co-identifications of <i>Citrobacter</i> isolates (<i>n</i> = 12) with other MBL-producing <i>Enterobacterales</i>. Despite lower outbreak potential, <i>Citrobacter</i> spp. constitute a significant MBL reservoir, requiring attention and surveillance.</p>

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NDM- or VIM-producing Citrobacter spp. in Poland, 2011-19: high genetic diversity with broader representation of ST8, ST18 and ST22 global clones

  • 期刊论文

  • 发表日期：

    2025年4月9日

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  • Radosław Izdebski,
  • Marta Biedrzycka,
  • Paweł Urbanowicz,
  • Dorota Żabicka,
  • Marek Gniadkowski

摘要

This study focused on genomic epidemiology of metallo-β-lactamase (MBL)-producing Citrobacter spp. in Poland. It included 118 isolates with VIM (n = 100), NDM (n = 17) or IMP (n = 1) enzymes from 2011 to 19, largely C. freundii (n = 94) of 33 sequence types (STs). Three globally-spread STs were more prevalent, namely ST18 (n = 15), ST8 (n = 11) and ST22 (n = 10), each diversified clonally and by VIM and NDM determinants. Only few outbreaks were evidenced, indicating MBL presence to result mainly from independent acquisitions, consistent with co-identifications of Citrobacter isolates (n = 12) with other MBL-producing Enterobacterales. Despite lower outbreak potential, Citrobacter spp. constitute a significant MBL reservoir, requiring attention and surveillance.